Chulanova A A, Smakhtin M Yu, Bobyntsev I I, Mishina E S, Artyushkova E B, Smakhtina A M
Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
Bull Exp Biol Med. 2023 Sep;175(5):700-703. doi: 10.1007/s10517-023-05929-5. Epub 2023 Oct 20.
We studied the reparative and antioxidant effects of Thymogen and its new structural analogues obtained by binding amino acid D-Ala to the N- or C-end of the peptide molecule in acute toxic hepatopathy. Intragastric administration of carbon tetrachloride for 5 days caused the development of fat degeneration of hepatocytes, a decrease in catalase activity, and an increase in malondialdehyde concentration. Administration of peptides suppressed oxidative peroxidation and stimulated reparative regeneration of hepatocytes; Thymogen analogues produced more pronounced hepatotropic and antioxidant effects than Thymogen. Inclusion of D-Ala enhanced the effect of Thymogen on the processes of regeneration in hepatocytes and the antioxidant effect under conditions of acute carbon tetrachloride hepatopathy. The highest efficiency was achieved when the amino acid was added to the C-end of the molecule.
我们研究了胸腺生成素及其通过将氨基酸D-丙氨酸结合到肽分子的N端或C端而获得的新结构类似物在急性中毒性肝病中的修复和抗氧化作用。连续5天胃内给予四氯化碳导致肝细胞脂肪变性、过氧化氢酶活性降低和丙二醛浓度升高。给予肽可抑制氧化过氧化反应并刺激肝细胞的修复性再生；胸腺生成素类似物比胸腺生成素产生更明显的肝向性和抗氧化作用。D-丙氨酸的加入增强了胸腺生成素对肝细胞再生过程的作用以及在急性四氯化碳肝病条件下的抗氧化作用。当氨基酸添加到分子的C端时，效率最高。
