Goda Motohiko, Yabu Naoto, Tominaga Norihisa, Machida Daisuke, Isomatsu Yukihisa, Suzuki Shinichi, Nitta Manabu, Komura Naohiro, Nakayama Naoki, Kiyokuni Masayoshi, Sugano Teruyasu, Masuda Munetaka
Department of Cardiovascular Surgery, Yokohama City University, Yokohama, Japan.
Department of Cardiology, Yokohama City University, Yokohama, Japan.
Artif Organs. 2018 Feb;42(2):235-239. doi: 10.1111/aor.12990. Epub 2017 Aug 29.
The AB5000 Circulatory Support System is paracorporeal pulsatile ventricular assist device. The AB Portable Driver is a portable console for this system. We experienced two cases with accelerated hemolysis while receiving support by the AB Portable Driver. The purpose of this study was to clarify the mechanical differences associated with the hemolysis between the AB5000 console and the AB Portable Driver. The mock circulatory system modeled by an AB5000 ventricle and a blood sampling bag of vinyl chloride was run with an AB5000 console or AB Portable Driver. The peak drive-line pressure, the mean arterial cannula pressure and the pumping rate of the VAD were recorded. The AB5000 console generated a peak drive-line pressure of 280-300 mm Hg in LVAD mode and 210-220 mm Hg in RVAD mode, approximately 100 mm Hg lower than officially documented. In contrast, the AB Portable Driver generated pressures of 310-330 mm Hg in LVAD mode and 230-250 mm Hg in RVAD mode, 65-95 mm Hg higher than officially documented. The AB Portable Driver console generates higher drive-line pressures than the AB5000 console, possibly explaining the accelerated hemolysis.
AB5000循环支持系统是一种体外搏动性心室辅助装置。AB便携式驱动装置是该系统的便携式控制台。我们在使用AB便携式驱动装置进行支持时遇到了两例加速溶血的情况。本研究的目的是阐明AB5000控制台与AB便携式驱动装置在溶血方面相关的机械差异。用AB5000心室和氯乙烯采血袋模拟的循环系统由AB5000控制台或AB便携式驱动装置运行。记录VAD的峰值驱动线压力、平均动脉插管压力和泵血速率。AB5000控制台在左心室辅助装置（LVAD）模式下产生的峰值驱动线压力为280 - 300 mmHg，在右心室辅助装置（RVAD）模式下为210 - 220 mmHg，比官方记录低约100 mmHg。相比之下，AB便携式驱动装置在LVAD模式下产生的压力为310 - 330 mmHg，在RVAD模式下为230 - 250 mmHg，比官方记录高65 - 95 mmHg。AB便携式驱动装置控制台产生的驱动线压力高于AB5000控制台，这可能解释了加速溶血的原因。
