Ducko C T, McGregor M L, Rosenberg G, Pierce W S
Department of Surgery, Pennsylvania State University, Philadelphia.
Artif Organs. 1994 Jun;18(6):454-60. doi: 10.1111/j.1525-1594.1994.tb02232.x.
The objective of this experiment was to investigate the relationship between blood damage and drive line dP/dt and valve type in the pneumatic ventricular assist device. Two mock circulatory loops were assembled using 70-ml Penn State pneumatic ventricular assist devices, one fitted with convexo-concave (CC) valves and one fitted with monostrut (MS) valves. Use of a compliance chamber established three ranges of drive line dP/dt values. Using bovine blood and the methods of generalized estimating equations, it was found that drive line dP/dt was significantly associated with the index of hemolysis (p = 0.00): the lower drive line dP/dt values yielded lower indices of hemolysis. In addition, this association differed between MS and CC valves (p = 0.01); the MS valves consistently yielded a higher index of hemolysis than the CC valves across all drive line dP/dt ranges. However, the relative hemolytic potential of each valve type became much closer at low drive line dP/dt values (2,000-3,000 mm Hg).
本实验的目的是研究气动心室辅助装置中血液损伤与驱动线dP/dt及瓣膜类型之间的关系。使用70毫升的宾夕法尼亚州立大学气动心室辅助装置组装了两个模拟循环回路，一个装有凸凹（CC）瓣膜，另一个装有单支柱（MS）瓣膜。使用顺应性腔室设定了三个驱动线dP/dt值范围。使用牛血并采用广义估计方程的方法，发现驱动线dP/dt与溶血指数显著相关（p = 0.00）：较低的驱动线dP/dt值产生较低的溶血指数。此外，MS瓣膜和CC瓣膜之间的这种关联有所不同（p = 0.01）；在所有驱动线dP/dt范围内，MS瓣膜始终产生比CC瓣膜更高的溶血指数。然而，在低驱动线dP/dt值（2,000 - 3,000毫米汞柱）时，每种瓣膜类型的相对溶血潜力变得更加接近。
