El-Salhy Magdy, Patcharatrakul Tanisa, Hatlebakk Jan Gunnar, Hausken Trygve, Gilja Odd Helge, Gonlachanvit Sutep
a Department of Medicine, Section for Gastroenterology , Stord Helse-Fonna Hospital , Stord , Norway.
b Department of Clinical Medicine , University of Bergen , Bergen , Norway.
Scand J Gastroenterol. 2017 Dec;52(12):1331-1339. doi: 10.1080/00365521.2017.1371793. Epub 2017 Aug 30.
The prevalence, gender distribution and clinical presentation of IBS differ between Asian and Western countries. This study aimed at studying and comparing enteroendocrine, Musashi 1 (Msi 1) and neurogenin 3 (neurog 3) cells in Thai and Norwegian IBS patients.
Thirty Thai and 61 Norwegian IBS patients as well as 20 Thai and 24 Norwegian controls were included. Biopsy samples were taken from each of the sigmoid colon and the rectum during a standard colonoscopy. The samples were immunostained for serotonin, peptide YY, oxyntomodulin, pancreatic polypeptide, somatostatin, Msi 1 and neurog 3. The densities of immunoreactive cells were determined with computerized image analysis.
The densities of several enteroendocrine cell types were altered in both the colon and rectum of both Thai and Norwegian IBS patients. Some of these changes were similar in Thai and Norwegian IBS patients, while others differed.
The findings of abnormal densities of the enteroendocrine cells in Thai patients support the notion that enteroendocrine cells are involved in the pathophysiology of IBS. The present observations highlight that IBS differs in Asian and Western countries, and show that the changes in large-intestine enteroendocrine cells in Thai and Norwegian IBS patients might be caused by different mechanisms.
肠易激综合征（IBS）在亚洲和西方国家的患病率、性别分布及临床表现存在差异。本研究旨在研究并比较泰国和挪威IBS患者的肠内分泌细胞、Musashi 1（Msi 1）和神经生成素3（neurog 3）细胞。
纳入30例泰国IBS患者、61例挪威IBS患者以及20例泰国对照者和24例挪威对照者。在标准结肠镜检查期间，从乙状结肠和直肠分别采集活检样本。样本进行5-羟色胺、肽YY、胃泌酸调节素、胰多肽、生长抑素、Msi 1和neurog 3的免疫染色。采用计算机图像分析确定免疫反应性细胞的密度。
泰国和挪威IBS患者的结肠和直肠中，几种肠内分泌细胞类型的密度均发生改变。其中一些变化在泰国和挪威IBS患者中相似，而另一些则不同。
泰国患者肠内分泌细胞密度异常的研究结果支持肠内分泌细胞参与IBS病理生理学的观点。目前的观察结果突出表明IBS在亚洲和西方国家存在差异，并表明泰国和挪威IBS患者大肠肠内分泌细胞的变化可能由不同机制引起。
