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Determination of carazolol in tissues of pigs by high-performance liquid chromatography.

作者信息

Rudolph M, Steinhart H

出版信息

J Chromatogr. 1987 Apr 17;392:371-8. doi: 10.1016/s0021-9673(01)94280-3.

DOI:10.1016/s0021-9673(01)94280-3
PMID:2885333
Abstract

A new and sensitive method is described for the determination of the beta-receptor blocker Carazolol, 4-(2-hydroxy-3-isopropylaminopropoxy)-carbazole, in different animal tissues. The procedure comprises extraction of Carazolol from tissue, clean-up by Kieselgel adsorption and high-performance liquid chromatographic separation with fluorimetric detection. The determination limit is 0.48 microgram/kg sample. The method has been verified by measuring Carazolol in liver, kidney and filet of a fattening pig treated with Carazolol before slaughtering.

摘要

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