扩展 ERG 在前列腺癌染色质景观和转录失调中的作用。
Expanding the effects of ERG on chromatin landscapes and dysregulated transcription in prostate cancer.
机构信息
Cancer Science Institute of Singapore, National University of Singapore, Singapore.
School of Biological Sciences, Nanyang Technological University, Singapore, and the Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore.
出版信息
Nat Genet. 2017 Aug 30;49(9):1294-1295. doi: 10.1038/ng.3944.
ERG overexpression in prostate cancers promotes the development of widespread changes in gene expression and chromatin landscapes, leading to redistribution of key transcription factors in prostate cancers positive for the TMPRSS2-ERG fusion gene. The overexpression of ERG is further assisted by the development of a super-enhancer in the ERG locus.
ERG 过表达在前列腺癌中促进了基因表达和染色质景观的广泛变化，导致 TMPRSS2-ERG 融合基因阳性的前列腺癌中关键转录因子的重新分布。ERG 基因座中超增强子的形成进一步协助了 ERG 的过表达。
Zotero 插件