Resch R, Haas H, Michlmayr G
Dtsch Med Wochenschr. 1979 Jul 20;104(29):1037-41. doi: 10.1055/s-0028-1129033.
Full remission of more than five years was observed in nine of 24 children with acute lymphatic leukaemia. They had been treated by a scheme similar to the Pinkel VII one, and all had been discharged from treatment. The immune status, bone marrow, radiological, neurological and psychosomatic studies, as well as various laboratory tests indicated that in seven of the children the findings, are essentially normal. But two children have lasting severe organ damage, portal fibrosis in one and bilateral intracerebral calcification in the other, both presumably due to the methotrexate treatment.
在24名急性淋巴细胞白血病患儿中,观察到9名患儿实现了超过五年的完全缓解。他们接受了与Pinkel VII方案类似的治疗方案,并且均已结束治疗。免疫状态、骨髓、放射学、神经学和身心研究以及各种实验室检查表明,其中7名儿童的检查结果基本正常。但有两名儿童存在持续性严重器官损伤,一名是门静脉纤维化,另一名是双侧脑内钙化,两者可能均归因于甲氨蝶呤治疗。