Allam Ahmed A
King Saud University, College of Science, Zoology Department, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Saudi J Biol Sci. 2017 Sep;24(6):1306-1321. doi: 10.1016/j.sjbs.2016.08.005. Epub 2016 Aug 28.
The present study aimed to elucidate the abnormalities in the development of rat brains, livers, kidney and behaviours after drinking desalinated seawater prenatally. Three types of drinking water were employed as an experimental probe (bottled water, filtered desalinated seawater and tap desalinated seawater) to investigate neurobehavioral and morphological changes in the development of pup rats. Female rats from each group were administered water from their birth until gestation and lactation. The 1st and 2nd generation pups were divided into three groups: Group C, mothers and pups administered with bottled drinking water (the control group); Group F, mothers and pups administered with filtered drinking water; Group T, mothers and pups administered with unfiltered desalinated seawater (tap water). Morphological changes (CNS aberration) and neurobehavioral changes were studied. The aberrations recorded in the tissues (brain, liver, kidney and spinal cord) of rats from groups T and F may be due to oxidative stress in these tissues such as reduced glutathione, lipid peroxidation, peroxidase and super oxide dismutase. In conclusion, drinking desalinated seawater for a long time may cause teratogenic effects in the development of New-born rats.
本研究旨在阐明产前饮用淡化海水后大鼠大脑、肝脏、肾脏发育及行为的异常情况。采用三种类型的饮用水作为实验探针（瓶装水、过滤后的淡化海水和自来水淡化海水）来研究幼鼠发育过程中的神经行为和形态变化。每组的雌性大鼠从出生到妊娠和哺乳期都给予相应的水。第一代和第二代幼崽分为三组：C组，母鼠和幼崽饮用瓶装饮用水（对照组）；F组，母鼠和幼崽饮用过滤后的饮用水；T组，母鼠和幼崽饮用未过滤的淡化海水（自来水）。研究了形态变化（中枢神经系统畸变）和神经行为变化。T组和F组大鼠组织（大脑、肝脏、肾脏和脊髓）中记录的畸变可能是由于这些组织中的氧化应激，如谷胱甘肽减少、脂质过氧化、过氧化物酶和超氧化物歧化酶。总之，长期饮用淡化海水可能会对新生大鼠的发育产生致畸作用。
