Clegg J C, Lloyd G
Lancet. 1987 Jul 25;2(8552):186-8. doi: 10.1016/s0140-6736(87)90767-7.
The Lister strain of vaccinia virus was used to construct a recombinant that expressed the nucleocapsid gene of Lassa virus. Guineapigs immunised with the recombinant virus were protected against challenge with Lassa virus, whereas control animals showed the usual disease course, including pyrexia, anorexia, viraemia, and death. These data indicate not only that protective immunity to Lassa fever can be evoked by an experimental vaccine, but also that this response can be mediated by an internal protein component of the virus.
痘苗病毒的李斯特株被用于构建一种表达拉沙病毒核衣壳基因的重组体。用重组病毒免疫的豚鼠对拉沙病毒的攻击具有抵抗力，而对照动物则呈现出通常的病程，包括发热、厌食、病毒血症和死亡。这些数据不仅表明实验性疫苗可以诱发对拉沙热的保护性免疫，而且还表明这种反应可以由病毒的一种内部蛋白质成分介导。
