[拉沙病毒核衣壳蛋白中抗原位点（B表位）的定位及初步特征]
[The localization and preliminary characteristics of antigenic sites (B epitopes) in the nucleocapsid protein of the Lassa virus].
作者信息
Vladyko A S, Bystrova S I, Malakhova I V, Kunitskaia L Ia, Lemeshko N N, Kras'ko A G, Kozhich A T, Lukashevich I S
出版信息
Vopr Virusol. 1993 Jan-Feb;38(1):30-4.
PMID:7521097
Abstract
Nucleocapsid protein of Lassa virus contains 4 epitope sites. Three of them were localized in amino acid position 123-1 27, 337-346, and 518-527. Monoclonal antibody 1108 specific to Lassa virus NP-protein reacted with 123-127 synthetic peptide in solid-phase ELISA and precipitated nucleocapsid proteins of Machupo, Tacaribe, and Mopeia arenaviruses in RIP.
摘要
拉沙病毒的核衣壳蛋白含有4个表位位点。其中3个位于氨基酸位置123 - 127、337 - 346和518 - 527。拉沙病毒NP蛋白特异性单克隆抗体1108在固相酶联免疫吸附测定中与123 - 127合成肽发生反应，并在放射免疫沉淀法中沉淀马丘波病毒、塔卡里伯病毒和莫佩亚沙粒病毒的核衣壳蛋白。
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