血浆氨基酸、肥胖与胃旁路手术后体重变化：氨基酸与体重反弹有关吗？
Plasma amino acids, adiposity, and weight change after gastric bypass surgery: are amino acids associated with weight regain?
机构信息
Section of Nutrition and Dietetics, Division of Medicine, Department of Clinical Service, Oslo University Hospital Aker, Oslo, Norway.
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
出版信息
Eur J Nutr. 2018 Oct;57(7):2629-2637. doi: 10.1007/s00394-017-1533-9. Epub 2017 Aug 30.
PURPOSE
Plasma concentrations of several amino acids (AAs) are positively correlated with obesity. The aim of this study was to examine if selected plasma AAs are associated with weight regain from 2 to 4 years after Roux-en-Y gastric bypass (RYGB).
METHODS
In a prospective study with 165 patients, we examined the relationship between plasma aromatic AAs (AAAs), branched chain AAs (BCAAs), and total cysteine (tCys) 2 years after RYGB, with BMI at 2 years and with weight change from 2 to 4 years after surgery. Analyses were adjusted for relevant covariates.
RESULT
The investigated AAs at 2 years correlated positively with BMI at 2 years (P ≤ 0.003 for all). BCAAs and AAAs at 2 years correlated inversely with % weight loss from 0 to 2 years (P = 0.002 and P = 0.001, respectively), while the association was not significant for tCys (r = -0.14, P = 0.08). Plasma tCys at 2 years correlated positively with BMI at 4 years (P = 0.010) and with weight regain from 2 to 4 years (P = 0.015).
CONCLUSION
Plasma AAAs, BCAAs, and tCys at 2 years were associated with BMI at 2 years. In addition, plasma AAAs and BCAAs at 2 years were associated with weight loss from 0 to 2 years, while tCys at 2 years was associated with weight regain from 2 to 4 years after RYGB. These results suggest that high tCys at 2 years may be used as a prognostic marker for future weight regain. The study was registered in ClinicalTrials.gov (NCT0 1270451).
目的
几种氨基酸（AA）的血浆浓度与肥胖呈正相关。本研究旨在检查罗伊氏胃旁路术（RYGB）后 2 至 4 年内，选定的血浆 AA 是否与体重反弹有关。
方法
在一项前瞻性研究中，我们对 165 例患者的血浆芳香族 AA（AAA）、支链 AA（BCAA）和总半胱氨酸（tCys）与 RYGB 后 2 年的 BMI 以及手术 2 至 4 年内的体重变化之间的关系进行了研究。分析调整了相关协变量。
结果
2 年内研究的 AA 与 2 年内的 BMI 呈正相关（所有 P ≤ 0.003）。2 年内的 BCAAs 和 AAA 与 0 至 2 年内的体重减轻百分比呈负相关（P = 0.002 和 P = 0.001），而 tCys 的相关性不显著（r = -0.14，P = 0.08）。2 年内的血浆 tCys 与 4 年内的 BMI 呈正相关（P = 0.010），与 2 至 4 年内的体重反弹呈正相关（P = 0.015）。
结论
2 年内的血浆 AAA、BCAA 和 tCys 与 2 年内的 BMI 相关。此外，2 年内的血浆 AAA 和 BCAAs 与 0 至 2 年内的体重减轻相关，而 2 年内的 tCys 与 RYGB 后 2 至 4 年内的体重反弹相关。这些结果表明，2 年内高 tCys 可作为未来体重反弹的预后标志物。该研究在 ClinicalTrials.gov 注册（NCT01270451）。
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