Hanvold Susanna E, Løken Elin B, Paus Sofie F, de Brisis Eva Rustad, Bjerkan Kirsti, Refsum Helga, Aas Anne-Marie
Division of Medicine, Department of Clinical Service, Section of Nutrition and Dietetics, Oslo University Hospital Aker, Oslo, Norway,
Obes Surg. 2015 Sep;25(9):1672-9. doi: 10.1007/s11695-015-1583-0.
The aim was to examine health benefits and lifestyle factors after Roux-en-Y gastric bypass (RYGB).
Patients (n = 165) were investigated 2 years after RYGB in relation to psychopharmaceutical drugs, employment status, type 2 diabetes mellitus (T2DM), hypertension, metabolic syndrome (MetS), body weight, physical activity (PA), and energy intake.
Excess weight loss (EWL) was 71.4 ± 20.6 %. Prevalence of T2DM, hypertension, and MetS was reduced (P < 0.001 for all). There were no changes in the use of psychopharmaceutical drugs (20.6 vs. 18.8 %, P = 0.549) or in the proportion of unemployed participants (37.7 vs. 33.3 %, P = 0.189) from pre- to post-surgery. Eighty-three percent achieved EWL ≥ 50 %. These subjects had a lower pre-surgery BMI. We found no differences in the prevalence of hypertension, T2DM, and MetS pre-surgery, but the prevalence was lower after surgery compared with subjects with EWL < 50 %.
RYGB induced remission of T2DM, hypertension, and MetS 2 years after surgery. The benefit was greatest in the group with EWL ≥ 50 %. Despite excellent weight loss, there was no change in the use of psychopharmaceutical drugs or proportion of unemployed participants.
目的是研究Roux-en-Y胃旁路术(RYGB)后的健康益处和生活方式因素。
对165例患者在RYGB术后2年进行调查,内容涉及精神药物使用情况、就业状况、2型糖尿病(T2DM)、高血压、代谢综合征(MetS)、体重、身体活动(PA)和能量摄入。
超重减轻(EWL)为71.4±20.6%。T2DM、高血压和MetS的患病率降低(均P<0.001)。从术前到术后,精神药物的使用情况(20.6%对18.8%,P=0.549)或未就业参与者的比例(37.7%对33.3%,P=0.189)没有变化。83%的患者EWL≥50%。这些患者术前BMI较低。我们发现术前高血压、T2DM和MetS的患病率没有差异,但与EWL<50%的患者相比,术后患病率较低。
RYGB术后2年可使T2DM、高血压和MetS缓解。EWL≥50%的组获益最大。尽管体重减轻效果良好,但精神药物的使用情况或未就业参与者的比例没有变化。