非裔美国乳腺癌患者在某些亚型和分期的预后比白人患者差。
African American patients with breast cancer have worse prognosis than white patients in certain subtypes and stages.
机构信息
Department of Surgery, Emory University, Atlanta, GA, USA.
Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, USA.
出版信息
Breast Cancer Res Treat. 2017 Dec;166(3):743-755. doi: 10.1007/s10549-017-4484-1. Epub 2017 Aug 30.
PURPOSE
Racial disparity of breast cancer in each subtype and substage is not clear.
METHODS
We reviewed 156,938 patients with breast cancer from 2010 to 2012 from the National Cancer Institute Surveillance, Epidemiology, and End Results database. Breast cancer was subtyped by hormone receptor (HR) and human epidermal growth factor 2 (HER2) status as HR+/HER2-, HR+/HER2+, HR-/HER2+, and HR-/HER2-.
RESULTS
African American (AA) patients had worse overall survival (OS) and breast cancer cause-specific survival (BCSS) in HR+/HER2- stages III and IV breast cancer and HR-/HER2+ stage IV cancer; they had worse OS but not BCSS in HR+ /HER2- stage II cancer and HR-/HER2- stage II cancer.
CONCLUSION
AA patients with breast cancer had worse survival in certain subtype and stage, especially in ER+ breast cancer.
目的
各亚型和各分期乳腺癌的种族差异尚不清楚。
方法
我们回顾了 2010 年至 2012 年期间来自美国国家癌症研究所监测、流行病学和最终结果数据库的 156938 例乳腺癌患者。乳腺癌通过激素受体（HR）和人表皮生长因子 2（HER2）状态进行亚型分类，分为 HR+/HER2-、HR+/HER2+、HR-/HER2+和 HR-/HER2-。
结果
在 HR+/HER2-III 期和 IV 期乳腺癌和 HR-/HER2+IV 期癌症中，非裔美国人（AA）患者的总体生存率（OS）和乳腺癌特异性生存率（BCSS）更差；在 HR+/HER2- II 期癌症和 HR-/HER2- II 期癌症中，他们的 OS 更差，但 BCSS 无差异。
结论
某些亚型和分期的乳腺癌患者中，非裔美国人患者的生存率更差，尤其是在 ER+乳腺癌中。
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