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地标系列——解决乳腺癌筛查中的差异:黑种女性的新建议。

The Landmark Series-Addressing Disparities in Breast Cancer Screening: New Recommendations for Black Women.

机构信息

Department of Surgery, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA.

Rena Rowan Breast Center, Abramson Cancer Center, The University of Pennsylvania, Philadelphia, PA, USA.

出版信息

Ann Surg Oncol. 2023 Jan;30(1):58-67. doi: 10.1245/s10434-022-12535-8. Epub 2022 Oct 3.

Abstract

Randomized, clinical trials have established the efficacy of screening mammography in improving survival from breast cancer for women through detection of early, asymptomatic disease. However, disparities in survival rates between black women and women from other racial and ethnic groups following breast cancer diagnosis persist. Various professional groups have different, somewhat conflicting, guidelines with regards to recommended age for commencing screening as well as recommended frequency of screening exams, but the trials upon which these recommendations are based were not specifically designed to examine benefit among black women. Furthermore, these recommendations do not appear to incorporate the unique epidemiological circumstances of breast cancer among black women, including higher rates of diagnosis before age 40 years and greater likelihood of advanced stage at diagnosis, into their formulation. In this review, we examined the epidemiologic and socioeconomic factors that are associated with breast cancer among black women and assess the implications of these factors for screening in this population. Specifically, we recommend that by no later than age 25 years, all black women should undergo baseline assessment for future risk of breast cancer utilizing a model that incorporates race (e.g., Breast Cancer Risk Assessment Tool [BCRAT], formerly the Gail model) and that this assessment should be conducted by a breast specialist or a healthcare provider (e.g., primary care physician or gynecologist) who is trained to assess breast cancer risk and is aware of the increased risks of early (i.e., premenopausal) and biologically aggressive (e.g., late-stage, triple-negative) breast cancer among black women.

摘要

随机临床试验已经证实,通过早期无症状疾病的检测,筛查乳房 X 光检查可提高女性乳腺癌的生存率。然而,黑人女性和其他种族和族裔群体的女性在乳腺癌诊断后的生存率仍存在差异。各种专业团体对于开始筛查的推荐年龄以及推荐的筛查检查频率有不同的、有些冲突的指南,但这些建议所依据的试验并非专门设计来检查黑人女性的获益。此外,这些建议似乎没有将黑人女性乳腺癌的独特流行病学情况纳入其制定过程,包括在 40 岁之前诊断的比率较高,以及在诊断时更有可能处于晚期的情况。在这篇综述中,我们检查了与黑人女性乳腺癌相关的流行病学和社会经济因素,并评估了这些因素对该人群筛查的影响。具体而言,我们建议所有黑人女性最迟应在 25 岁时,利用纳入种族的模型(例如,乳腺癌风险评估工具[BCRAT],前身为 Gail 模型)对未来乳腺癌风险进行基线评估,并且应通过接受过评估乳腺癌风险培训并了解黑人女性中早期(即绝经前)和生物学侵袭性(例如晚期、三阴性)乳腺癌风险增加的乳房专家或医疗保健提供者(例如初级保健医生或妇科医生)来进行这种评估。

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本文引用的文献

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Global guidelines for breast cancer screening: A systematic review.全球乳腺癌筛查指南:系统评价。
Breast. 2022 Aug;64:85-99. doi: 10.1016/j.breast.2022.04.003. Epub 2022 Apr 19.
4
Impact of molecular subtype and race on HR+, HER2- breast cancer survival.分子亚型和种族对 HR+、HER2- 乳腺癌生存的影响。
Breast Cancer Res Treat. 2021 Oct;189(3):845-852. doi: 10.1007/s10549-021-06342-0. Epub 2021 Jul 31.
7
Call to action: breast cancer screening recommendations for Black women.行动呼吁:针对黑人女性的乳腺癌筛查建议。
Breast Cancer Res Treat. 2021 May;187(1):295-297. doi: 10.1007/s10549-021-06207-6. Epub 2021 Mar 26.
8
Cancer Statistics, 2021.癌症统计数据,2021.
CA Cancer J Clin. 2021 Jan;71(1):7-33. doi: 10.3322/caac.21654. Epub 2021 Jan 12.

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