Degand Nicolas, Dautremer Justine, Pilmis Benoît, Ferroni Agnès, Lanternier Fanny, Bruneau Julie, Hermine Olivier, Blanche Stéphane, Nassif Xavier, Lortholary Olivier, Lecuit Marc
Université Paris Descartes - Sorbonne Paris Cité, Laboratoire de Microbiologie, Hôpital Necker-Enfants Malades, Assistance Publique - Hôpitaux de Paris, Paris, France.
CHU de Nice, Laboratoire de Bactériologie, 151 route St Antoine de Ginestière, BP 3079, 06202, Nice, Cedex 3, France.
J Clin Immunol. 2017 Oct;37(7):727-731. doi: 10.1007/s10875-017-0437-z. Epub 2017 Aug 31.
ᅟ: Helicobacter bilis is a commensal bacterium causing chronic hepatitis and colitis in mice. In humans, enterohepatic Helicobacter spp. are associated with chronic hepatobiliary diseases.
We aimed at understanding the microbial etiology in a patient with X-linked agammaglobulinemia presenting with suppurative cholangitis.
16S rDNA PCR directly performed on a liver biopsy retrieved DNA of H. bilis.
Clinical outcome resulted in the normalization of clinical and biological parameters under antibiotic treatment by a combination of ceftriaxone, metronidazole, and doxycyclin followed by a 2-week treatment with moxifloxacin and a 2-month treatment with azithromycin.
In conclusion, these data suggest a specific clinical and microbiological approach in patients with humoral deficiency in order to detect H. bilis hepatobiliary diseases.
幽门螺杆菌是一种共生细菌，可导致小鼠慢性肝炎和结肠炎。在人类中，肝肠螺杆菌属与慢性肝胆疾病有关。
我们旨在了解一名患有X连锁无丙种球蛋白血症并伴有化脓性胆管炎患者的微生物病因。
对肝活检标本直接进行16S rDNA PCR，获取了幽门螺杆菌的DNA。
临床结果显示，在使用头孢曲松、甲硝唑和强力霉素联合抗生素治疗后，临床和生物学参数恢复正常，随后用莫西沙星治疗2周，阿奇霉素治疗2个月。
总之，这些数据表明，对于体液免疫缺陷患者，应采用特定的临床和微生物学方法来检测幽门螺杆菌引起的肝胆疾病。
