Laboratory of Experimental Bacteriology, National Institute of Pediatrics, Mexico City, Mexico.
Immunodeficiency Research Unit, National Institute of Pediatrics, Mexico City, Mexico.
Front Cell Infect Microbiol. 2022 Feb 4;11:807136. doi: 10.3389/fcimb.2021.807136. eCollection 2021.
The genus is classified into two main groups according to its habitat: gastric and enterohepatic. Patients with X-linked agammaglobulinemia (XLA) appear to be associated with invasive infection with enterohepatic non-Helicobacter pylori species (NHPH), mainly and . Such infections are difficult to control and have a high potential for recurrence. The spectrum of illnesses caused by these species includes recurrent fever, bacteremia, arthritis, osteomyelitis, cellulitis, abdominal abscesses, and pyoderma gangrenosum-like ulcer. The presence of these is particularly difficult to diagnose and eradicate, as they are very fastidious bacteria and present resistance to several types of antibiotics. We report two clinical cases of XLA patients infected with H. These infections were chronic in these patients and could not be eradicated in one of them. We also review the cases of enterohepatic non- species (NHPH) in patients with this inborn error of immunity.
根据其栖息地，该属分为两个主要组：胃型和肠肝型。X 连锁无丙种球蛋白血症（XLA）患者似乎与肠肝型非幽门螺杆菌物种（NHPH）的侵袭性感染有关，主要是 和 。这些感染难以控制，且有很高的复发风险。这些物种引起的疾病谱包括反复发热、菌血症、关节炎、骨髓炎、蜂窝织炎、腹部脓肿和坏疽性脓皮病样溃疡。这些 的存在特别难以诊断和根除，因为它们是非常挑剔的细菌，对几种类型的抗生素有耐药性。我们报告了两例 XLA 患者感染 H. 的临床病例。这些感染在这些患者中是慢性的，其中一例无法根除。我们还回顾了患有这种先天性免疫缺陷的肠肝非物种（NHPH）的病例。
