通过16S rRNA基因分析在一名患有X连锁低丙种球蛋白血症患者的腹部脓肿中鉴定出一种独特的幽门螺杆菌。
Identification of a unique Helicobacter species by 16S rRNA gene analysis in an abdominal abscess from a patient with X-linked hypogammaglobulinemia.
作者信息
Han S, Schindel C, Genitsariotis R, Märker-Hermann E, Bhakdi S, Maeurer M J
机构信息
Department of Medical Microbiology, Johannes Gutenberg University, Mainz, Germany.
出版信息
J Clin Microbiol. 2000 Jul;38(7):2740-2. doi: 10.1128/JCM.38.7.2740-2742.2000.
Abstract
A unique Helicobacter species, MZ640285, was isolated from a patient with X-linked hypogammaglobulinemia suffering from recurrent abdominal abscesses and was identified by 16S rRNA gene sequence analysis. In the phylogenetic tree, the isolate fell into a cluster which included Flexispira rappini, Helicobacter bilis, and Helicobacter sp. strain Mainz. Helicobacters are being increasingly recognized as pathogens in immunocompromised hosts. These fastidious bacteria are not easily cultured in the routine diagnostic laboratory, and this is the first report of their identification by 16S rRNA gene sequencing performed directly from a clinical specimen.
摘要
从一名患有X连锁低丙种球蛋白血症且反复出现腹部脓肿的患者中分离出一种独特的幽门螺杆菌菌株MZ640285，并通过16S rRNA基因序列分析进行鉴定。在系统发育树中，该分离株属于一个包含拉平弯曲螺杆菌、胆汁幽门螺杆菌和 Mainz幽门螺杆菌菌株的簇。幽门螺杆菌越来越被认为是免疫功能低下宿主中的病原体。这些苛求菌在常规诊断实验室中不易培养，这是首次直接从临床标本中通过16S rRNA基因测序对其进行鉴定的报告。
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