Department of Gastroenterology, Mianyang Central Hospital, Sichuan, China 621000.
Biomed Res Int. 2022 Aug 9;2022:1837850. doi: 10.1155/2022/1837850. eCollection 2022.
Gut microbiota coevolve with humans to achieve a symbiotic relationship, which ultimately leads to physiological homeostasis. A variety of diseases can occur once this balance is disrupted. () is an opportunistic pathogen in humans, triggering multiple diseases, including inflammatory bowel disease (IBD). IBD is a chronic immunologically mediated inflammation of the human gastrointestinal tract, and its occurrence is closely related to the gut microbiota. Several studies have demonstrated that colonization is associated with IBD, and its mechanism is related to host immunity. However, few studies have investigated these mechanisms of action. Therefore, this article is aimed at reviewing these studies and summarizing the mechanisms of -induced IBD from two perspectives: adaptive immunity and innate immunity. Furthermore, this study provides a preliminary discussion on treating -related IBD. In addition, we also demonstrated that played an important role in promoting the carcinogenesis of IBD and discussed its mechanism.
肠道微生物与人类共同进化，达到共生关系，从而实现生理平衡。一旦这种平衡被打破，就会引发多种疾病。（）是人类中的机会致病菌，可引发多种疾病，包括炎症性肠病（IBD）。IBD 是一种人类胃肠道的慢性免疫介导炎症，其发生与肠道微生物群密切相关。多项研究表明，定植与 IBD 有关，其机制与宿主免疫有关。然而，很少有研究探讨这些作用机制。因此，本文旨在综述这些研究，并从适应性免疫和固有免疫两个方面总结诱导 IBD 的机制。此外，本研究还对治疗相关 IBD 进行了初步探讨。此外，我们还证明在促进 IBD 的癌变中发挥了重要作用，并探讨了其机制。
