Chin Yu-Tang, Cheng Guei-Yun, Shih Ya-Jung, Lin Chi-Yu, Lin Shan-Jen, Lai Hsuan-Yu, Whang-Peng Jacqueline, Chiu Hsien-Chung, Lee Sheng-Yang, Fu Earl, Tang Heng-Yuan, Lin Hung-Yun, Liu Leroy F
Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan.
Department of Dentistry, Wan-Fang Medical Center, Taipei Medical University, Taipei, Taiwan.
Ann N Y Acad Sci. 2017 Sep;1403(1):101-108. doi: 10.1111/nyas.13433. Epub 2017 Aug 30.
Periodontitis is an inflammatory disease of the supporting tissues of the teeth induced by periodontopathic bacteria that results in the progressive destruction of periodontal tissues. Treatment of periodontitis is painful and time-consuming. Recently, herbal medicines have been considered for use in treating inflammation-related diseases, including periodontitis. Resveratrol and its derivative 2,3,5,4'-tetrahydroxystilbene-2-O-β-glucoside (THSG), a polyphenol extracted from Polygonum multiflorum, have anti-inflammatory properties and other medical benefits. Here, we highlight the importance of resveratrol and its glycosylated derivative as possible complementary treatments for periodontitis and their potential for development as innovative therapeutic strategies. In addition, we present evidence and discuss the mechanisms of action of resveratrol and THSG on periodontitis, focusing on Porphyromonas gingivalis-induced inflammatory responses in human gingival fibroblasts and animal modeling of ligature-induced periodontitis. We also illuminate the signal transduction pathways and the cytokines involved.
牙周炎是一种由牙周病原菌引起的牙齿支持组织的炎症性疾病，会导致牙周组织的渐进性破坏。牙周炎的治疗既痛苦又耗时。最近，草药已被考虑用于治疗包括牙周炎在内的炎症相关疾病。白藜芦醇及其衍生物2,3,5,4'-四羟基二苯乙烯-2-O-β-葡萄糖苷（THSG），一种从何首乌中提取的多酚，具有抗炎特性和其他医学益处。在此，我们强调白藜芦醇及其糖基化衍生物作为牙周炎可能的辅助治疗方法的重要性以及它们作为创新治疗策略的开发潜力。此外，我们提供证据并讨论白藜芦醇和THSG对牙周炎的作用机制，重点关注牙龈卟啉单胞菌诱导的人牙龈成纤维细胞炎症反应以及结扎诱导的牙周炎动物模型。我们还阐明了相关的信号转导途径和细胞因子。
