Dos Santos Vinicius Ruan Neves, Frazão Deborah Ribeiro, Ferreira Railson de Oliveira, Mendes Paulo Fernando Santos, Baia-da-Silva Daiane Claydes, Souza-Monteiro Deiweson, Bittencourt Leonardo Oliveira, de Moura João Daniel Mendonça, Perdigão José Messias, Teixeira Bruno José Brito, Varela Everton Luiz Pompeu, Balbinot Gabriela de Souza, Percário Sandro, Rogez Herve, Rösing Cassiano Kuchenbecker, Collares Fabrício Mezzomo, Lima Rafael Rodrigues
Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
Center for Valorization of Amazonian Bioactive Compounds, College of Biotechnology, Federal University of Pará, Belém 66075-110, PA, Brazil.
Antioxidants (Basel). 2022 Sep 26;11(10):1902. doi: 10.3390/antiox11101902.
Açaí ( Mart.) juice is rich in phenolic compounds with high antioxidant capacity. It has been observed that the use of antioxidants may be an additional strategy to nonsurgical periodontal therapy as well as to prevent alveolar bone loss. Thus, the objective of this study was to investigate the effects of açaí supplementation on experimental periodontitis in rats. Twenty male (Wistar) rats were assigned into control, açaí, experimental periodontitis, and experimental periodontitis with açaí supplementation groups. Periodontitis was induced by placing ligatures around the lower first molars. Animals in the açaí groups received 0.01 mL/g of clarified açaí juice for 14 days by intragastric gavage. At the end of the experimental period, blood was collected to assess the reduced glutathione (GSH), Trolox equivalent antioxidant capacity (TEAC), and lipid peroxidation (TBARS) levels. Moreover, hemimandibles were analyzed by micro-computed tomography (micro-CT) for alveolar bone loss and bone quality. Açaí supplementation increased blood total antioxidant capacity and decreased lipid peroxidation. It also reduced alveolar bone loss when compared to the experimental periodontitis group. Moreover, clarified açaí per se modulated the oxidative biochemistry and bone microstructure. Thus, açaí may be considered a viable alternative for managing periodontal oxidative stress and preventing alveolar bone loss.
阿萨伊（Mart.）果汁富含具有高抗氧化能力的酚类化合物。据观察，使用抗氧化剂可能是非手术牙周治疗以及预防牙槽骨丧失的一种额外策略。因此，本研究的目的是调查补充阿萨伊对大鼠实验性牙周炎的影响。将20只雄性（Wistar）大鼠分为对照组、阿萨伊组、实验性牙周炎组和补充阿萨伊的实验性牙周炎组。通过在第一下磨牙周围放置结扎丝诱导牙周炎。阿萨伊组的动物通过灌胃给予0.01 mL/g澄清的阿萨伊果汁，持续14天。在实验期结束时，采集血液以评估还原型谷胱甘肽（GSH）、Trolox等效抗氧化能力（TEAC）和脂质过氧化（TBARS）水平。此外，通过微型计算机断层扫描（micro-CT）分析半侧下颌骨的牙槽骨丧失和骨质量。补充阿萨伊增加了血液总抗氧化能力并降低了脂质过氧化。与实验性牙周炎组相比，它还减少了牙槽骨丧失。此外，澄清的阿萨伊本身调节了氧化生物化学和骨微观结构。因此，阿萨伊可被认为是管理牙周氧化应激和预防牙槽骨丧失的一种可行替代方法。
