Department of Physiology and Pharmacology, Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Maurice Müller Laboratories, Department of Clinical Research (DKF), UVCM, University Hospital, Bern, Switzerland.
Immunol Rev. 2017 Sep;279(1):63-69. doi: 10.1111/imr.12575.
All mucosal surfaces are colonized with a vast number of microbes, which are essential for stimulating and regulating the immune system. While intrinsic and innate mechanisms exist to promote a strong barrier between the microbiota and the host to ensure compartmentalization, the microbiota is also able to induce robust adaptive immunity. In this review, we discuss the interplay between the microbiota and the adaptive immune system, with a focus on the induction of mucosal and systemic antibody responses and newly defined roles of maternal antibodies. We also highlight recent studies that aim to decipher microbial antigen-specificity of the T-cell compartment.
所有的黏膜表面都定植着大量的微生物，这些微生物对于刺激和调节免疫系统至关重要。虽然存在内在和先天的机制来促进微生物群和宿主之间的强大屏障以确保分隔，但微生物群也能够诱导强大的适应性免疫。在这篇综述中，我们讨论了微生物群和适应性免疫系统之间的相互作用，重点讨论了黏膜和系统抗体反应的诱导以及母体抗体的新定义作用。我们还强调了最近旨在破译 T 细胞区室中微生物抗原特异性的研究。
