Yan Jiali, Wu Zhenhu, Deng Li, Huang Chunzhen, Jing Yuting, Chen Xiao-Yin, Xu Yinji
Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510120, Guangdong Province, China.
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510403, Guangdong Province, China.
Heliyon. 2024 May 19;10(11):e31512. doi: 10.1016/j.heliyon.2024.e31512. eCollection 2024 Jun 15.
Accumulating evidence has highlighted the influence of the gut microbiota on lung immunity. We examined the effects of changes in intestinal microecology on the development of Chronic Obstructive Pulmonary Disease (COPD) and identified microbial biomarkers for acute exacerbations of COPD (AECOPD). Fecal samples were collected from 30 patients with stable COPD, 30 patients with AECOPD, and 10 healthy individuals. Fecal microbiological profiles were analyzed using 16S rRNA gene sequencing. The results showed a distinct difference in the bacterial community composition between the AECOPD, COPD, and healthy control groups. The COPD and AECOPD groups had higher levels of Firmicutes but lower levels of Bacteroidetes compared to the healthy control group at the phylum level. At the genus level, there was an increased abundance of Lachnoclostridium, Alistipes, Streptococcus, and Prevotella in COPD and AECOPD patients. Increasing levels of Lachnoclostridium and Prevotella may indicate an acute exacerbation of COPD. This study identified specific microbial biomarkers associated with AECOPD and characterized the composition of gut microbiota in patients with AECOPD.
越来越多的证据凸显了肠道微生物群对肺部免疫的影响。我们研究了肠道微生态变化对慢性阻塞性肺疾病（COPD）发展的影响，并确定了慢性阻塞性肺疾病急性加重（AECOPD）的微生物生物标志物。收集了30例稳定期COPD患者、30例AECOPD患者和10名健康个体的粪便样本。使用16S rRNA基因测序分析粪便微生物谱。结果显示，AECOPD组、COPD组和健康对照组之间的细菌群落组成存在明显差异。在门水平上，与健康对照组相比，COPD组和AECOPD组的厚壁菌门水平较高，而拟杆菌门水平较低。在属水平上，COPD和AECOPD患者中毛螺菌属、艾氏菌属、链球菌属和普雷沃菌属的丰度增加。毛螺菌属和普雷沃菌属水平的升高可能表明COPD急性加重。本研究确定了与AECOPD相关的特定微生物生物标志物，并对AECOPD患者的肠道微生物群组成进行了特征分析。
