Ukai Tomohiko, Tabuchi Takahiro, Iso Hiroyasu
Department of Epidemiology and Clinical Research, The Research Institute of Tuberculosis.
Division of Epidemiology, School of Public Health, Tohoku University Graduate School of Medicine.
Environ Health Prev Med. 2025;30:23. doi: 10.1265/ehpm.24-00294.
Studies have shown that married couples often share similar lifestyles, as well as lifestyle-associated conditions such as diabetes, hypertension, and hyperlipidemia. This study aims to prospectively investigate the association between an individual's development of a non-communicable disease and the subsequent development of the same condition in their spouse.
This population-based cohort study utilized 12 waves of annual prospective surveys from 2005 onwards in Japan, with a discrete-time design. A total of 9,417 middle-aged couples (18,834 participants; discrete-time observations = 118,876) were included. Each participant whose spouse had developed one of six conditions was propensity score-matched with five controls whose spouses had not been diagnosed with the condition: diabetes [n = 1374 vs n = 6870], hypertension [n = 2657 vs n = 13285], hypercholesterolemia [n = 3321 vs n = 16605], stroke [n = 567 vs n = 2835], coronary heart disease (CHD) [n = 1093 vs n = 5465] or cancer [n = 923 vs n = 4615]. Using conditional logistic regression, we assessed participants' development of the same condition within three years following their spouse's diagnosis.
Participants whose spouses had developed diabetes, hypertension, hypercholesterolemia, or CHD were more likely to develop the same condition within three years. The odds ratios (ORs) and 95% confidence intervals (CIs) were: 1.96 (1.53-2.50), 1.20 (1.06-1.36), 1.63 (1.47-1.81) and 1.43 (1.05-1.95), respectively. No significant associations were observed in stroke [1.69 (0.80-3.58)] or cancer [1.08 (0.75-1.54)].
Spouses of individuals recently diagnosed with certain metabolic conditions are at a higher risk of developing those conditions themselves. These findings may provide valuable guidance for targeting and personalizing chronic disease screening and prevention efforts.
研究表明，已婚夫妇通常有着相似的生活方式，以及与生活方式相关的疾病，如糖尿病、高血压和高脂血症。本研究旨在前瞻性地调查个体患非传染性疾病与配偶随后患相同疾病之间的关联。
这项基于人群的队列研究利用了日本从2005年起的12次年度前瞻性调查，采用离散时间设计。共纳入9417对中年夫妇（18834名参与者；离散时间观察值 = 118876）。配偶患有六种疾病之一的每位参与者与五名配偶未被诊断出患有该疾病的对照进行倾向得分匹配：糖尿病（1374例对6870例）、高血压（2657例对13285例）、高胆固醇血症（3321例对16605例）、中风（567例对2835例）、冠心病（CHD，1093例对5465例）或癌症（923例对4615例）。我们使用条件逻辑回归评估参与者在其配偶被诊断后的三年内患相同疾病的情况。
配偶患有糖尿病、高血压、高胆固醇血症或冠心病的参与者在三年内患相同疾病的可能性更高。优势比（OR）和95%置信区间（CI）分别为：分别为1.96（1.53 - 2.50）、1.20（1.06 - 1.36）、1.63（1.47 - 1.81）和1.43（1.05 - 1.95）。在中风[1.69（0.80 - 3.58）]或癌症[1.08（0.75 - 1.54）]方面未观察到显著关联。
最近被诊断患有某些代谢性疾病的个体的配偶自身患这些疾病的风险更高。这些发现可能为针对慢性病筛查和预防工作提供有价值的指导，并实现个性化。
