Haifu Hospital of the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.
BJOG. 2017 Aug;124 Suppl 3:87-92. doi: 10.1111/1471-0528.14747.
To investigate the short- and long-term efficacy and influential factors of focused ultrasound for the treatment of non-neoplastic epithelial disorders of the vulva (NNEDV).
A retrospective observational study.
A gynaecologic department in a single centre in China.
Patients with NNEDV were included in this study: 85 patients were diagnosed with lichen simplex chronicus (LSC), 44 patients with vulva lichen sclerosus (VLS), and seven patients with lichen planus (LP).
A total of 136 eligible patients with NNEDV were treated with focused ultrasound. After the treatment, based on changes in the degree of symptom severity and local skin signs (lesion size, skin colour and elasticity) before and after treatment, the treatment effectiveness for each patient was assessed. We further analysed the relations among pathologic type, age, course and curative rate. Statistical analysis was performed using the Chi-square (McNemar) test.
Improvement in the symptoms and physical signs and the predictive factors.
Symptom relief was observed in all patients. The appearance and colour of the vulva returned to normal after the ultrasound treatment. Complete remission (CR) occurred in 68 of 136 (50%) patients (41 patients with LSC and 12 patients with VLS). The response rate was 93.38% (127/136). Seven patients who had a poor response to the first session of treatment were treated again with ultrasound therapy and a good response was observed. No severe complications were observed. There was no significant difference in treatment results among the different pathological types (P > 0.05). However, the course of the disease and the age of the patients were related to the treatment results (P < 0.05).
NNEDV can be treated with focused ultrasound effectively and safely. The course of the disease and the age of the patients may be predictive factors.
Patients with non-neoplastic epithelial disorders of the vulva can be safely and effectively treated with focused ultrasound. No significant difference in treatment results was observed between the different types of non-neoplastic epithelial disorders of the vulva.
探讨聚焦超声治疗外阴非瘤样上皮性疾病（NNEDV）的近期和远期疗效及其影响因素。
回顾性观察性研究。
中国某单一中心的妇科部门。
本研究纳入了 NNEDV 患者：85 例诊断为慢性单纯性外阴苔藓（LSC），44 例诊断为外阴硬化性苔藓（VLS），7 例诊断为扁平苔藓（LP）。
共对 136 例符合条件的 NNEDV 患者进行了聚焦超声治疗。治疗后，根据治疗前后症状严重程度和局部皮肤体征（病变大小、皮肤颜色和弹性）的变化，对每位患者的治疗效果进行评估。我们进一步分析了病理类型、年龄、病程与治愈率的关系。采用卡方（McNemar）检验进行统计学分析。
症状和体征改善情况及预测因素。
所有患者的症状均得到缓解。外阴超声治疗后，外阴外观和颜色恢复正常。136 例患者中完全缓解（CR）68 例（LSC 41 例，VLS 12 例），有效率为 93.38%（127/136）。7 例首次治疗反应不佳的患者再次行超声治疗，反应良好。未观察到严重并发症。不同病理类型之间治疗效果无显著差异（P>0.05）。然而，疾病病程和患者年龄与治疗效果相关（P<0.05）。
聚焦超声治疗 NNEDV 安全有效。疾病病程和患者年龄可能是预测因素。
患有外阴非瘤样上皮性疾病的患者可以通过聚焦超声安全有效地进行治疗。不同类型的外阴非瘤样上皮性疾病的治疗效果无显著差异。
