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骨骼肌的适应反应:有何证据?

The adaptive response of skeletal muscle: What is the evidence?

机构信息

Department of Musculoskeletal Biology, Institute of Ageing & Chronic Diseases, University of Liverpool, William Henry Duncan Building, 6 West Derby Street, Liverpool, L7 8TX, United Kingdom.

出版信息

Muscle Nerve. 2018 Apr;57(4):531-541. doi: 10.1002/mus.25949. Epub 2017 Sep 23.

DOI:10.1002/mus.25949
PMID:28857207
Abstract

Adult skeletal muscle is capable of adapting its properties in response to changing functional demands. This now sounds like a statement of the obvious, and many people assume it has always been this way. A mere 40 years ago, however, the picture was entirely different. In this Review and personal memoir, I outline the scientific context in which the theory was generated, the objections to it from entrenched opinion, and the way those objections were progressively met. The material should be of some historical interest, but, more importantly, it collects together the full range of evidence on which the current paradigm is based. Muscle Nerve 57: 531-541, 2018.

摘要

成人骨骼肌能够根据功能需求的变化来调整其特性。现在看来,这似乎是不言而喻的,但许多人认为这种情况一直如此。然而,就在 40 年前,情况完全不同。在这篇综述和个人回忆录中,我概述了该理论产生的科学背景,以及来自固有观点的反对意见,以及这些反对意见是如何逐步得到解决的。这些材料应该具有一定的历史意义,但更重要的是,它汇集了当前范式所依据的全部证据。《肌肉与神经》57:531-541, 2018.

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