Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, U.S.A.
Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, U.S.A.
Biochem Soc Trans. 2024 Aug 28;52(4):1921-1926. doi: 10.1042/BST20240201.
Skeletal muscle stem cells (MuSCs) display distinct behavior crucial for tissue maintenance and repair. Upon activation, MuSCs exhibit distinct modes of division: symmetric division, facilitating either self-renewal or differentiation, and asymmetric division, which dictates divergent cellular fates. This review explores the nuanced dynamics of MuSC division and the molecular mechanisms governing this behavior. Furthermore, it introduces a novel phenomenon observed in a subset of MuSCs under hypertrophic stimuli termed division-independent differentiation. Insights into the underlying mechanisms driving this process are discussed, alongside its broader implications for muscle physiology.
骨骼肌干细胞（MuSCs）表现出独特的行为，对组织维持和修复至关重要。在激活后，MuSCs 表现出不同的分裂模式：对称分裂，促进自我更新或分化，以及不对称分裂，决定了不同的细胞命运。本综述探讨了 MuSC 分裂的细微动态及其行为的分子机制。此外，它还介绍了在肥大刺激下观察到的一部分 MuSCs 中的一种新现象，称为不依赖分裂的分化。讨论了驱动这一过程的潜在机制及其对肌肉生理学的更广泛影响。
