IFITM3 过表达预示 Ivor Lewis 食管癌根治术后 IIA 期食管鳞癌患者预后不良。
Overexpression of IFITM3 predicts poor prognosis in stage IIA esophageal squamous cell carcinoma after Ivor Lewis esophagectomy.
机构信息
Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
出版信息
Thorac Cancer. 2017 Nov;8(6):592-599. doi: 10.1111/1759-7714.12488. Epub 2017 Aug 30.
BACKGROUND
Recent research has shown that IFITM3 plays an important role in the tumorigenesis of many malignancies. We investigated the clinicopathological variables and prognostic value of IFITM3 in stage IIA esophageal squamous cell carcinoma (ESCC) patients.
METHODS
Immunohistochemistry and Western blot analysis were used to examine IFITM3 expression in tumor specimens. The relationships between IFITM3 expression and clinicopathological variables, as well as the five-year survival and recurrence status of patients, were analyzed.
RESULTS
IFITM3 was aberrantly expressed in tumor tissue. Statistical analysis showed a close correlation of IFITM3 expression with T tumor status (P = 0.004). Additionally, IFITM3 overexpression, advanced T status, poor degree of differentiation, and large tumor size were not only associated with poor survival but were high lymphatic metastatic recurrence predictors in ESCC patients (P < 0.05).
CONCLUSION
Our data indicated that IFITM3 overexpression may predict poor prognosis in stage IIA ESCC patients after Ivor Lewis esophagectomy.
背景
最近的研究表明，IFITM3 在许多恶性肿瘤的肿瘤发生中发挥着重要作用。我们研究了 IFITM3 在 IIA 期食管鳞癌（ESCC）患者中的临床病理变量和预后价值。
方法
免疫组织化学和 Western blot 分析用于检测肿瘤标本中 IFITM3 的表达。分析 IFITM3 表达与临床病理变量之间的关系，以及患者的五年生存和复发情况。
结果
IFITM3 在肿瘤组织中异常表达。统计学分析显示 IFITM3 表达与 T 肿瘤状态密切相关（P=0.004）。此外，IFITM3 过表达、T 分期较晚、低分化程度和肿瘤较大不仅与生存不良相关，而且还是 ESCC 患者高淋巴转移复发的预测因素（P<0.05）。
结论
我们的数据表明，Ivor Lewis 食管切除术治疗后，IFITM3 过表达可能预示着 IIA 期 ESCC 患者预后不良。
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