Hefei Fourth People's Hospital, Anhui Mental Health Center.
Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University.
Neuropsychology. 2018 Feb;32(2):199-205. doi: 10.1037/neu0000383. Epub 2017 Aug 31.
Recent evidence suggests the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of suicidal behavior. Because schizophrenia patients usually have high suicide rates and numerous studies have suggested that BDNF may contribute to the psychopathology of schizophrenia, we hypothesized that the functional polymorphism of BDNF (Val66Met) was associated with suicide attempts in patients with schizophrenia in a Chinese Han population.
This polymorphism was genotyped in 825 chronic schizophrenia patients with (n = 123) and without (n = 702) suicide attempts and 445 healthy controls without a history of suicide attempts using a case-control design. The schizophrenia symptoms were assessed by the Positive and Negative Syndrome Scale.
There were no significant differences in BDNF Val66Met genotype and allele distributions between the patients and healthy controls. However, we found the Val allele (p = .023) and the Val/Val genotypes (p = .058) to be associated with a history of suicide attempts. Moreover, some clinical characteristics, including age and cigarettes smoked each day, interacted with the BDNF gene variant and appeared to play an important role in suicide attempts among schizophrenia patients.
The BDNF Val66Met polymorphism itself and its interaction with some clinical variables may influence suicide attempts among schizophrenia patients. (PsycINFO Database Record
最近的证据表明脑源性神经营养因子（BDNF）在自杀行为的病理生理学中起作用。由于精神分裂症患者通常有很高的自杀率，并且许多研究表明 BDNF 可能导致精神分裂症的精神病理学，因此我们假设 BDNF（Val66Met）的功能多态性与中国汉族人群中精神分裂症患者的自杀企图有关。
采用病例对照设计，对 825 例有（n=123）和无（n=702）自杀企图的慢性精神分裂症患者和 445 名无自杀企图史的健康对照者进行了 BDNF Val66Met 多态性基因分型。使用阳性和阴性综合征量表评估精神分裂症症状。
患者和健康对照组之间 BDNF Val66Met 基因型和等位基因分布无显著差异。然而，我们发现 Val 等位基因（p=0.023）和 Val/Val 基因型（p=0.058）与自杀企图史相关。此外，一些临床特征，包括年龄和每天吸烟的香烟数量，与 BDNF 基因变异相互作用，似乎在精神分裂症患者的自杀企图中起重要作用。
BDNF Val66Met 多态性本身及其与某些临床变量的相互作用可能会影响精神分裂症患者的自杀企图。
