Dobbie Allison M
Division of Pediatric Otolaryngology, Department of Otolaryngology, University of Colorado School of Medicine/Children's Hospital Colorado, Colorado Springs, Colorado, USA.
Curr Opin Otolaryngol Head Neck Surg. 2017 Oct;25(5):390-395. doi: 10.1097/MOO.0000000000000401.
The current article reviews the current literature related to congenital cytomegalovirus (CMV)-related hearing loss. The discussion will focus on the epidemiology, pathogenesis, and clinical presentation of human CMV infection as it pertains to hearing loss. Current methods of CMV diagnosis with a focus on the evolving trend toward broader neonatal screening protocols will also be explored. Discussion of medical, surgical, and audiologic management of the condition will also be addressed.
Much of the current research on this topic is focused on improving detection of CMV through screening programs. Some advances in understanding cochlear pathogenesis have also been made.
Congenital CMV infection remains an important cause of hearing loss in infants and children. Early detection of CMV infection can broaden treatment options and allow for improved hearing and language outcome for patients with CMV-associated sensorineural hearing loss.
本文综述了与先天性巨细胞病毒（CMV）相关听力损失的当前文献。讨论将聚焦于人类CMV感染与听力损失相关的流行病学、发病机制及临床表现。还将探讨CMV诊断的当前方法，重点关注更广泛的新生儿筛查方案的发展趋势。也将讨论该病症的医学、外科及听力学管理。
目前关于该主题的许多研究都集中在通过筛查项目改善CMV检测。在理解耳蜗发病机制方面也取得了一些进展。
先天性CMV感染仍然是婴幼儿听力损失的重要原因。CMV感染的早期检测可以拓宽治疗选择，并改善CMV相关感音神经性听力损失患者的听力和语言结局。
