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Chronic morphine treatment reduces the incidence of ventricular arrhythmias in the isolated rat heart induced by dynorphin1-13 or myocardial ischemia and reperfusion.

作者信息

Wong T M, Lee A Y

出版信息

Neurosci Lett. 1987 Jun 1;77(1):61-5. doi: 10.1016/0304-3940(87)90607-0.

DOI:10.1016/0304-3940(87)90607-0
PMID:2885792
Abstract

We have studied the effects of a daily morphine injection for 2 weeks on induction of naloxone-reversible arrhythmias in the Langendorff isolated rat heart preparation caused by dynorphin1-13 or myocardial ischemia and reperfusion. Chronic morphine treatment significantly reduced the incidence and severity of arrhythmias and increased recovery following both administration of dynorphin and myocardial ischemia and reperfusion. The results support the notion that myocardial ischemia and reperfusion induce cardiac arrhythmias via endogenous opioid peptides.

摘要

相似文献

1
Chronic morphine treatment reduces the incidence of ventricular arrhythmias in the isolated rat heart induced by dynorphin1-13 or myocardial ischemia and reperfusion.
Neurosci Lett. 1987 Jun 1;77(1):61-5. doi: 10.1016/0304-3940(87)90607-0.
2
Effects of dynorphin1-13 on cardiac rhythm and cyclic adenosine monophosphate (cAMP) levels in the isolated perfused rat heart.强啡肽1-13对离体灌注大鼠心脏节律及环磷酸腺苷（cAMP）水平的影响。
Neurosci Lett. 1987 Oct 5;80(3):289-92. doi: 10.1016/0304-3940(87)90469-1.
3
Effect of alprazolam on ischemia and reperfusion-induced ventricular arrhythmias in the isolated perfused rat heart.阿普唑仑对离体灌注大鼠心脏缺血再灌注诱导的室性心律失常的影响。
Pharmacology. 1989;39(2):129-36. doi: 10.1159/000138588.
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Naloxone blocks the cardiac effects of myocardial ischaemia and reperfusion in the rat isolated heart.纳洛酮可阻断大鼠离体心脏中心肌缺血及再灌注的心脏效应。
Clin Exp Pharmacol Physiol. 1985 Jul-Aug;12(4):373-8. doi: 10.1111/j.1440-1681.1985.tb00885.x.
5
Preconditioning of ischemic myocardium: reperfusion-induced arrhythmias.缺血心肌预处理：再灌注诱导的心律失常。
Am J Physiol. 1987 Dec;253(6 Pt 2):H1470-6. doi: 10.1152/ajpheart.1987.253.6.H1470.
6
Protective effects of captopril against ischemia/reperfusion-induced ventricular arrhythmias in vitro and in vivo.卡托普利对体外和体内缺血/再灌注诱导的室性心律失常的保护作用。
Am J Med. 1988 Mar 11;84(3A):67-74. doi: 10.1016/0002-9343(88)90207-0.
7
Ischemia- and reperfusion-induced arrhythmias are prevented by putrescine.腐胺可预防缺血及再灌注诱导的心律失常。
Eur J Pharmacol. 1991 Feb 26;194(1):7-10. doi: 10.1016/0014-2999(91)90116-8.
8
Cardioprotective effects of morphine on rat heart suffering from ischemia and reperfusion.
Chin Med J (Engl). 2003 Jul;116(7):1059-62.
9
Chronic pantoprazole administration and ischemia--reperfusion arrhythmias in vivo in rats--antiarrhythmic or arrhythmogenic?长期服用泮托拉唑与大鼠体内缺血-再灌注心律失常——抗心律失常还是致心律失常？
Cardiovasc Ther. 2015 Apr;33(2):27-34. doi: 10.1111/1755-5922.12107.
10
Morphine and the endogenous opioid dynorphin in the brain attenuate digoxin-induced arrhythmias in guinea pigs.大脑中的吗啡和内源性阿片肽强啡肽可减轻地高辛诱导的豚鼠心律失常。
Pharmacol Toxicol. 1992 Nov;71(5):353-60. doi: 10.1111/j.1600-0773.1992.tb00561.x.

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阿片受体与心肌保护：阿片激动剂是否具有心肌保护作用？
Clin Drug Investig. 1998;15(5):445-54. doi: 10.2165/00044011-199815050-00009.
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Cardiovascular actions of the kappa-agonist, U-50,488H, in the absence and presence of opioid receptor blockade.κ-激动剂U-50,488H在有无阿片受体阻断情况下的心血管作用
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