使用扫频光学相干断层扫描技术对视神经乳头 drusen 进行体积测量。
Volumetric Measurement of Optic Nerve Head Drusen Using Swept-Source Optical Coherence Tomography.
作者信息
Tsikata Edem, Verticchio Vercellin Alice C, Falkenstein Iryna, Poon Linda Yi-Chieh, Brauner Stacey, Khoueir Ziad, Miller John B, Chen Teresa C
机构信息
*Department of Ophthalmology, Harvard Medical School †Massachusetts Eye and Ear, Boston, MA ‡University Eye Clinic, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia, Italy §Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan ∥Beirut Eye and Ear, Nose, and Throat Specialist Hospital, Beirut, Lebanon.
出版信息
J Glaucoma. 2017 Sep;26(9):798-804. doi: 10.1097/IJG.0000000000000707.
PURPOSE
To describe new software tools for quantifying optic nerve head drusen volume using 3-dimensional (3D) swept-source optical coherence tomography (SS-OCT) volumetric scans.
MATERIALS AND METHODS
SS-OCT was used to acquire raster volume scans of 8 eyes of 4 patients with bilateral optic nerve head drusen. The scans were manually segmented by 3 graders to identify the drusen borders, and thereafter total drusen volumes were calculated. Linear regression was performed to study the relationships between drusen volume, retinal nerve fiber layer thickness, and Humphrey visual field mean deviation.
RESULTS
In the 8 study eyes, drusen volumes ranged between 0.24 to 1.05 mm. Visual field mean deviation decreased by ∼20 dB per cubic millimeter increase in drusen volume, and the coefficient of correlation of the linear regression was 0.92. In this small patient series, visual field defects were detected when drusen volume was larger than about 0.2 mm.
CONCLUSIONS
Software tools have been developed to quantify the size of OHND using SS-OCT volume scans.
目的
描述使用三维（3D）扫频光学相干断层扫描（SS-OCT）容积扫描来量化视神经乳头 drusen 体积的新软件工具。
材料与方法
使用 SS-OCT 对 4 例双侧视神经乳头 drusen 患者的 8 只眼睛进行光栅容积扫描。扫描由 3 名分级人员手动分割以识别 drusen 边界，然后计算 drusen 总体积。进行线性回归以研究 drusen 体积、视网膜神经纤维层厚度和 Humphrey 视野平均偏差之间的关系。
结果
在 8 只研究眼中，drusen 体积在 0.24 至 1.05 立方毫米之间。随着 drusen 体积每增加一立方毫米，视野平均偏差降低约 20 dB，线性回归的相关系数为 0.92。在这个小患者系列中，当 drusen 体积大于约 0.2 立方毫米时检测到视野缺损。
结论
已开发出软件工具，使用 SS-OCT 容积扫描来量化视神经乳头 drusen 的大小。
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