Skaat Alon, Muylaert Stephanie, Mogil Rachel S, Furlanetto Rafael L, Netto Camila F, Banik Rudrani, Liebmann Jeffrey M, Ritch Robert, Park Sung Chul
Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai.
Goldschleger Eye Institute, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
J Glaucoma. 2017 Dec;26(12):1095-1100. doi: 10.1097/IJG.0000000000000783.
The purpose of this study is to assess the relationships between optic nerve head drusen (ONHD) volume, retinal nerve fiber layer (RNFL) thickness and visual field (VF) loss.
Patients with ONHD and no other ocular or systemic conditions that can affect RNFL or VF were enrolled. Serial enhanced depth imaging (EDI) optical coherence tomography (OCT) B-scans of the optic nerve head (interval between scans, ~30 μm) were obtained from each participant. ONHD volume was calculated for each eye by delineating the ONHD masses in each OCT B-scan using 3-dimensional reconstruction software.
A total of 47 eyes (28 patients) with ONHD were included (mean age, 57±16 y). ONHD volume varied considerably [0.265±0.227 (range, 0.005 to 0.855)] mm. Linear and quadratic regression analyses demonstrated that ONHD volume is significantly associated with both global average RNFL thickness (linear R=0.531, quadratic R=0.557; P<0.001) and VF mean deviation (linear R=0.519, quadratic R=0.522; P<0.001). ONHD were most prevalent in the nasal quadrant (46 eyes, 98%), followed by superior, inferior and temporal quadrants [35 (74%), 30 (64%), and 16 (34%) eyes respectively]. The proportion of eyes with OCT RNFL defects (81%; 38/47 eyes) was significantly greater than that with VF defects (60%; 28/47 eyes) (P<0.001). RNFL defects were detected in 10 of the 19 eyes with no VF defects. RNFL defects were detected in all 28 eyes with VF defects.
ONHD volume generally correlates with structural and functional optic nerve damage.
本研究旨在评估视神经乳头 drusen（ONHD）体积、视网膜神经纤维层（RNFL）厚度与视野（VF）损失之间的关系。
纳入患有 ONHD 且无其他可影响 RNFL 或 VF 的眼部或全身疾病的患者。从每位参与者获取视神经乳头的系列增强深度成像（EDI）光学相干断层扫描（OCT）B 扫描图像（扫描间隔约 30μm）。使用三维重建软件在每个 OCT B 扫描图像中勾勒出 ONHD 团块，计算每只眼睛的 ONHD 体积。
共纳入 47 只患有 ONHD 的眼睛（28 名患者）（平均年龄 57±16 岁）。ONHD 体积差异很大[0.265±0.227（范围 0.005 至 0.855）]mm。线性和二次回归分析表明，ONHD 体积与整体平均 RNFL 厚度（线性 R = 0.531，二次 R = 0.557；P < 0.001）和 VF 平均偏差（线性 R = 0.519，二次 R = 0.522；P < 0.001）均显著相关。ONHD 在鼻侧象限最为常见（46 只眼睛，98%），其次是上方、下方和颞侧象限[分别为 35（74%）、30（64%）和 16（34%）只眼睛]。OCT RNFL 缺陷的眼睛比例（81%；38/47 只眼睛）显著高于 VF 缺陷的眼睛比例（60%；28/47 只眼睛）（P < 0.001）。在 19 只无 VF 缺陷的眼睛中有 10 只检测到 RNFL 缺陷。在所有 28 只患有 VF 缺陷的眼睛中均检测到 RNFL 缺陷。
ONHD 体积通常与视神经的结构和功能损伤相关。
