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感染:淋病疫苗有效性的原理验证。

Infection: Proof of principle for effectiveness of a gonorrhoea vaccine.

机构信息

WHO Collaborating Centre for Gonorrhoea and other STIs, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University Hospital and Örebro University, S. Grevrosengatan 2, SE-701 85 Örebro, Sweden.

Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97330, USA.

出版信息

Nat Rev Urol. 2017 Nov;14(11):643-644. doi: 10.1038/nrurol.2017.139. Epub 2017 Aug 31.

DOI:10.1038/nrurol.2017.139
PMID:28858332
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5735823/
Abstract

Antimicrobial resistance in compromises gonorrhoea treatment globally and vaccines might be the only sustainable solution for gonorrhoea control. A new study for the first time provides a proof of principle for protection with ~31% effectiveness against gonorrhoea, owing to cross-protection by the outer membrane vesicle serogroup B vaccine (MeNZB).

摘要

抗菌药物耐药性使全球淋病治疗受到影响,而疫苗可能是控制淋病的唯一可持续解决方案。一项新的研究首次提供了一个原理性的证据,证明外膜囊泡血清群 B 疫苗 (MeNZB) 具有约 31%的交叉保护效力,可预防淋病。

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本文引用的文献

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Effectiveness of a group B outer membrane vesicle meningococcal vaccine against gonorrhoea in New Zealand: a retrospective case-control study.新西兰 B 群脑膜炎球菌外膜囊泡疫苗预防淋病的效果:一项回顾性病例对照研究。
Lancet. 2017 Sep 30;390(10102):1603-1610. doi: 10.1016/S0140-6736(17)31449-6. Epub 2017 Jul 10.
2
Antimicrobial resistance in Neisseria gonorrhoeae: Global surveillance and a call for international collaborative action.淋病奈瑟菌的抗菌药物耐药性:全球监测及国际合作行动呼吁
PLoS Med. 2017 Jul 7;14(7):e1002344. doi: 10.1371/journal.pmed.1002344. eCollection 2017 Jul.
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Experimental vaccine induces Th1-driven immune responses and resistance to Neisseria gonorrhoeae infection in a murine model.实验疫苗诱导 Th1 驱动的免疫应答,并在小鼠模型中抵抗淋病奈瑟菌感染。
Mucosal Immunol. 2017 Nov;10(6):1594-1608. doi: 10.1038/mi.2017.11. Epub 2017 Mar 1.
4
Future prospects for new vaccines against sexually transmitted infections.针对性传播感染的新型疫苗的未来前景。
Curr Opin Infect Dis. 2017 Feb;30(1):77-86. doi: 10.1097/QCO.0000000000000343.
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Proteomics-driven Antigen Discovery for Development of Vaccines Against Gonorrhea.蛋白质组学驱动的抗原发现用于开发抗淋病疫苗
Mol Cell Proteomics. 2016 Jul;15(7):2338-55. doi: 10.1074/mcp.M116.058800. Epub 2016 May 2.
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Is gonococcal disease preventable? The importance of understanding immunity and pathogenesis in vaccine development.淋球菌病可以预防吗?了解免疫和发病机制在疫苗研发中的重要性。
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