O'Neill K A, Gertner S B
Pharmacol Biochem Behav. 1987 Apr;26(4):683-6. doi: 10.1016/0091-3057(87)90596-x.
Two structurally distinct H2 antagonists, cimetidine and BMY 25,368, were injected into the cerebral ventricles of mice. Both drugs produced reductions in locomotor activity and rotorod latencies. The effects of the H2 antagonists on locomotor activity were attenuated by the H2 agonist, impromidine, as well as by the H1 antagonist, chlorpheniramine. When given alone, chlorpheniramine had no effect on locomotor activity, while impromidine reduced locomotion. These data suggest that histaminergic receptors may mediate important actions on arousal and sedation mechanisms.
将两种结构不同的H2拮抗剂西咪替丁和BMY 25,368注射到小鼠的脑室中。两种药物均使运动活性和转棒潜伏期降低。H2拮抗剂对运动活性的作用被H2激动剂英普咪定以及H1拮抗剂氯苯那敏减弱。单独给予时，氯苯那敏对运动活性无影响，而英普咪定减少运动。这些数据表明组胺能受体可能介导对觉醒和镇静机制的重要作用。
