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From drugs to devices and back again: chemical vagal nerve stimulation for the treatment of heart failure.从药物到设备，再回归药物：化学性迷走神经刺激治疗心力衰竭
Cardiovasc Res. 2017 Sep 1;113(11):1270-1272. doi: 10.1093/cvr/cvx142.
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Neurotransmission to parasympathetic cardiac vagal neurons in the brain stem is altered with left ventricular hypertrophy-induced heart failure.在左心室肥厚所致心力衰竭时，脑干中副交感神经心脏迷走神经元的神经传递会发生改变。
Am J Physiol Heart Circ Physiol. 2015 Oct;309(8):H1281-7. doi: 10.1152/ajpheart.00445.2015. Epub 2015 Sep 14.
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Cervical vagus nerve stimulation augments spontaneous discharge in second- and higher-order sensory neurons in the rat nucleus of the solitary tract.颈迷走神经刺激增强大鼠孤束核中二级及更高级感觉神经元的自发放电。
Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H354-H367. doi: 10.1152/ajpheart.00070.2017. Epub 2017 May 5.
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[Chronic cervical vagal stimulation. Mechanisms of action and clinical relevance for heart failure].[慢性颈迷走神经刺激。心力衰竭的作用机制及临床意义]
Herz. 2015 Nov;40(7):952-8. doi: 10.1007/s00059-015-4364-6.
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Vagus nerve stimulation mitigates intrinsic cardiac neuronal remodeling and cardiac hypertrophy induced by chronic pressure overload in guinea pig.迷走神经刺激减轻豚鼠慢性压力超负荷诱导的心脏固有神经元重塑和心脏肥大。
Am J Physiol Heart Circ Physiol. 2016 May 15;310(10):H1349-59. doi: 10.1152/ajpheart.00939.2015. Epub 2016 Mar 18.
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Chronic activation of hypothalamic oxytocin neurons improves cardiac function during left ventricular hypertrophy-induced heart failure.下丘脑催产素神经元的慢性激活可改善左心室肥厚诱导的心力衰竭期间的心脏功能。
Cardiovasc Res. 2017 Sep 1;113(11):1318-1328. doi: 10.1093/cvr/cvx084.
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Vagus nerve stimulation: from pre-clinical to clinical application: challenges and future directions.迷走神经刺激：从临床前到临床应用：挑战与未来方向。
Heart Fail Rev. 2011 Mar;16(2):195-203. doi: 10.1007/s10741-010-9216-0.
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Vagus Nerve Stimulation for the Treatment of Heart Failure: The INOVATE-HF Trial.迷走神经刺激治疗心力衰竭：INOVATE-HF 试验。
J Am Coll Cardiol. 2016 Jul 12;68(2):149-58. doi: 10.1016/j.jacc.2016.03.525. Epub 2016 Apr 4.
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Short‑term vagal nerve stimulation improves left ventricular function following chronic heart failure in rats.短期迷走神经刺激可改善大鼠慢性心力衰竭后的左心室功能。
Mol Med Rep. 2015 Aug;12(2):1709-16. doi: 10.3892/mmr.2015.3597. Epub 2015 Apr 7.
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Vagal stimulation in heart failure.心力衰竭中的迷走神经刺激。
J Cardiovasc Transl Res. 2014 Apr;7(3):310-20. doi: 10.1007/s12265-014-9540-1. Epub 2014 Feb 6.

引用本文的文献

1
Organotopic organization of the porcine mid-cervical vagus nerve.猪颈中段迷走神经的器官特异性组织
Front Neurosci. 2023 May 2;17:963503. doi: 10.3389/fnins.2023.963503. eCollection 2023.
2
Vagus nerve stimulation optimized cardiomyocyte phenotype, sarcomere organization and energy metabolism in infarcted heart through FoxO3A-VEGF signaling.迷走神经刺激通过 FoxO3A-VEGF 信号优化梗死心脏中的心肌细胞表型、肌节组织和能量代谢。
Cell Death Dis. 2020 Nov 12;11(11):971. doi: 10.1038/s41419-020-03142-0.
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MicroCT optimisation for imaging fascicular anatomy in peripheral nerves.用于外周神经束解剖成像的 microCT 优化。
J Neurosci Methods. 2020 May 15;338:108652. doi: 10.1016/j.jneumeth.2020.108652. Epub 2020 Mar 13.
4
Avoiding off-target effects in electrical stimulation of the cervical vagus nerve: Neuroanatomical tracing techniques to study fascicular anatomy of the vagus nerve.避免颈迷走神经电刺激的脱靶效应：研究迷走神经束解剖结构的神经解剖示踪技术。
J Neurosci Methods. 2019 Sep 1;325:108325. doi: 10.1016/j.jneumeth.2019.108325. Epub 2019 Jun 28.
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How Heart Rate Should Be Controlled in Patients with Atherosclerosis and Heart Failure.如何控制动脉粥样硬化和心力衰竭患者的心率。
Curr Atheroscler Rep. 2018 Sep 17;20(11):54. doi: 10.1007/s11883-018-0757-3.

本文引用的文献

1
Chronic activation of hypothalamic oxytocin neurons improves cardiac function during left ventricular hypertrophy-induced heart failure.下丘脑催产素神经元的慢性激活可改善左心室肥厚诱导的心力衰竭期间的心脏功能。
Cardiovasc Res. 2017 Sep 1;113(11):1318-1328. doi: 10.1093/cvr/cvx084.
2
Optimal Titration Is Important to Maximize the Beneficial Effects of Vagal Nerve Stimulation in Chronic Heart Failure.最佳滴定对于最大化慢性心力衰竭患者迷走神经刺激的有益效果很重要。
J Card Fail. 2016 Aug;22(8):631-8. doi: 10.1016/j.cardfail.2016.04.021. Epub 2016 May 2.
3
Vagus Nerve Stimulation for the Treatment of Heart Failure: The INOVATE-HF Trial.迷走神经刺激治疗心力衰竭：INOVATE-HF 试验。
J Am Coll Cardiol. 2016 Jul 12;68(2):149-58. doi: 10.1016/j.jacc.2016.03.525. Epub 2016 Apr 4.
4
Vagus nerve stimulation mitigates intrinsic cardiac neuronal remodeling and cardiac hypertrophy induced by chronic pressure overload in guinea pig.迷走神经刺激减轻豚鼠慢性压力超负荷诱导的心脏固有神经元重塑和心脏肥大。
Am J Physiol Heart Circ Physiol. 2016 May 15;310(10):H1349-59. doi: 10.1152/ajpheart.00939.2015. Epub 2016 Mar 18.
5
Central-peripheral neural network interactions evoked by vagus nerve stimulation: functional consequences on control of cardiac function.迷走神经刺激诱发的中枢-外周神经网络相互作用：对心脏功能控制的功能影响
Am J Physiol Heart Circ Physiol. 2015 Nov 15;309(10):H1740-52. doi: 10.1152/ajpheart.00557.2015. Epub 2015 Sep 14.
6
The sympathetic/parasympathetic imbalance in heart failure with reduced ejection fraction.射血分数降低的心力衰竭中的交感神经/副交感神经失衡。
Eur Heart J. 2015 Aug 7;36(30):1974-82b. doi: 10.1093/eurheartj/ehv087. Epub 2015 May 13.
7
Autonomic regulation therapy for the improvement of left ventricular function and heart failure symptoms: the ANTHEM-HF study.自主神经调节治疗改善左心室功能和心力衰竭症状：ANTHEM-HF 研究。
J Card Fail. 2013 Sep;19(9):655-60. doi: 10.1016/j.cardfail.2013.07.002.
8
Vagus nerve stimulation improves left ventricular function in a canine model of chronic heart failure.迷走神经刺激改善慢性心力衰竭犬模型的左心室功能。
Eur J Heart Fail. 2013 Dec;15(12):1319-26. doi: 10.1093/eurjhf/hft118. Epub 2013 Jul 24.
9
Pathological ventricular remodeling: mechanisms: part 1 of 2.病理性心室重构：机制：第 1 部分，共 2 部分。
Circulation. 2013 Jul 23;128(4):388-400. doi: 10.1161/CIRCULATIONAHA.113.001878.
10
Vagus nerve stimulation: from pre-clinical to clinical application: challenges and future directions.迷走神经刺激：从临床前到临床应用：挑战与未来方向。
Heart Fail Rev. 2011 Mar;16(2):195-203. doi: 10.1007/s10741-010-9216-0.

From drugs to devices and back again: chemical vagal nerve stimulation for the treatment of heart failure.

作者信息

Ripplinger Crystal M

机构信息

Department of Pharmacology, University of California Davis, 2219A Tupper Hall, Davis, CA 95616, USA.

出版信息

Cardiovasc Res. 2017 Sep 1;113(11):1270-1272. doi: 10.1093/cvr/cvx142.

DOI:10.1093/cvr/cvx142
PMID:28859301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5852535/
Abstract
摘要