Erasme hospital, Department of Psychiatry and Sleep Laboratory, Université Libre de Bruxelles, ULB, Brussels, Belgium.
School of Public Health SPU-ESP, Department of Biostatistics, Université Libre de Bruxelles, ULB, Brussels, Belgium.
Psychiatry Res. 2017 Dec;258:387-395. doi: 10.1016/j.psychres.2017.08.061. Epub 2017 Aug 26.
In primary insomnia, specific dynamics of hyperarousal are evident during the night. Similarly, in major depression, many elements also favor of the presence of hyperarousal. Thus, it would be interesting to investigate if hyperarousal presents the same dynamic in major depression. Polysomnographic data from 30 healthy controls, 66 patients with major depression and prodromal insomnia, and 86 primary insomnia sufferers recruited from the sleep laboratory database were studied for whole night and thirds of the night. Insomnia sufferers and patients with depression exhibit a similar polysomnographic pattern both for whole night (increased sleep latency and WASO and reduced SWS and REM) and thirds of night (increased WASO at first and last thirds, reduced SWS in first third, and reduced in REM in first and last third). No alterations were detected during the second third of the night. Just as in primary insomnia, the hyperarousal phenomenon is found mainly in major depression with prodromal insomnia during the sleep-onset period and the first and last thirds of the night, but lesser during the second third of the night. These specific dynamics of hyperarousal may aid in the understanding of the particular relationship between insomnia and depression.
在原发性失眠中，夜间存在明显的过度觉醒特异性动力学。同样，在重度抑郁症中，许多因素也有利于过度觉醒的存在。因此，研究重度抑郁症中是否存在相同的过度觉醒动力学将是有趣的。从睡眠实验室数据库中招募了 30 名健康对照者、66 名有前驱性失眠和重度抑郁症的患者以及 86 名原发性失眠患者，对他们整晚和三分之一的睡眠时间进行了多导睡眠图数据研究。失眠症患者和抑郁症患者在整晚（睡眠潜伏期和觉醒时间增加，慢波睡眠和 REM 减少）和三分之一的睡眠时间（第一和最后三分之一的觉醒时间增加，第一三分之一的慢波睡眠减少，第一和最后三分之一的 REM 减少）都表现出相似的多导睡眠图模式。在第二三分之一的夜间没有发现变化。就像原发性失眠一样，过度觉醒现象主要发生在有前驱性失眠的重度抑郁症患者中，主要发生在睡眠起始期和夜间的第一和最后三分之一，而在第二三分之一的夜间较少发生。这些过度觉醒的特定动力学可能有助于理解失眠和抑郁症之间的特殊关系。
