Hein Matthieu, Lanquart Jean-Pol, Loas Gwénolé, Hubain Philippe, Linkowski Paul
Department of Psychiatry and Sleep Laboratory, Erasme Hospital, Université Libre de Bruxelles, ULB, Brussels, Belgium.
Department of Psychiatry and Sleep Laboratory, Brussels, Belgium.
BMC Psychiatry. 2017 Jul 28;17(1):273. doi: 10.1186/s12888-017-1438-4.
Our aim is to verify empirically the existence of a major depressed subgroup with a similar polysomnographic pattern as primary insomnia, including at rapid eye movement sleep level.
The polysomnographic data from 209 untreated individuals (30 normative, 84 primary insomnia sufferers, and 95 major depressed patients with objective insomnia) who were recruited retrospectively from the Erasme hospital database were studied for the whole night and thirds of the night.
Primary insomnia sufferers and major depressed patients with objective insomnia exhibit a similar polysomnographic pattern both for the whole night (excess of wake after sleep onset, deficit in slow-wave sleep/rapid eye movement sleep, and non-shortened rapid eye movement latency) and thirds of the night (excess of wake after sleep onset at first and last third, deficit in slow-wave sleep in first third, and deficit in rapid eye movement sleep in first and last third), including at rapid eye movement sleep level.
In our study, we demonstrated that major depressed patients with objective insomnia showed a similar polysomnographic pattern as primary insomnia, including at rapid eye movement sleep level, which supports the hypothesis of a common pathophysiology that could be hyperarousal. This opens new avenues for understanding the pathophysiology of major depression with objective insomnia.
我们的目的是通过实证验证是否存在一个重度抑郁亚组，其多导睡眠图模式与原发性失眠相似，包括在快速眼动睡眠水平上。
对从伊拉斯谟医院数据库中回顾性招募的209名未经治疗的个体（30名正常个体、84名原发性失眠患者和95名伴有客观失眠的重度抑郁患者）的多导睡眠图数据进行了整夜和夜间三个时段的研究。
原发性失眠患者和伴有客观失眠的重度抑郁患者在整夜（睡眠起始后觉醒过多、慢波睡眠/快速眼动睡眠不足以及快速眼动睡眠潜伏期未缩短）和夜间三个时段（第一个和最后一个时段睡眠起始后觉醒过多、第一个时段慢波睡眠不足以及第一个和最后一个时段快速眼动睡眠不足）均表现出相似的多导睡眠图模式，包括在快速眼动睡眠水平上。
在我们的研究中，我们证明伴有客观失眠的重度抑郁患者表现出与原发性失眠相似的多导睡眠图模式，包括在快速眼动睡眠水平上，这支持了可能是过度觉醒的共同病理生理学假说。这为理解伴有客观失眠的重度抑郁的病理生理学开辟了新途径。
