Igari Kimihiro, Kudo Toshifumi, Toyofuku Takahiro, Inoue Yoshinori
Division of Vascular and Endovascular Surgery, Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Vasc Health Risk Manag. 2017 Aug 23;13:317-323. doi: 10.2147/VHRM.S139892. eCollection 2017.
We evaluated the endothelial function of patients with Buerger disease using peripheral arterial tonometry test, and examined the factors that are significantly correlated with the endothelial dysfunction in these patients. We performed the peripheral arterial tonometry test in 22 patients with Buerger disease. We recorded the patients' characteristics, including ankle brachial pressure index and reactive hyperemia index, which reflect the endothelial dysfunction. We divided the patients with Buerger disease into the conservative treatment and lumbar sympathectomy group. While the reactive hyperemia index was not significantly different between these two groups, the ankle brachial pressure index was significantly different (1.12 versus 0.83, =0.003). Furthermore, the reactive hyperemia index was significantly correlated with the ankle brachial pressure index value in the patients in the lumbar sympathectomy group (=0.848, =0.005). Given that patients with Buerger disease show impairment of the sympathetic nervous system, we should consider the after-effects of such an impaired system on the condition of these patients. The patients treated with lumbar sympathectomy might be more appropriate to evaluate their endothelial function by a peripheral arterial tonometry test.
我们使用外周动脉张力测定试验评估了血栓闭塞性脉管炎患者的内皮功能，并研究了与这些患者内皮功能障碍显著相关的因素。我们对22例血栓闭塞性脉管炎患者进行了外周动脉张力测定试验。我们记录了患者的特征，包括反映内皮功能障碍的踝臂压力指数和反应性充血指数。我们将血栓闭塞性脉管炎患者分为保守治疗组和腰交感神经切除术组。虽然这两组之间的反应性充血指数没有显著差异，但踝臂压力指数有显著差异（1.12对0.83，P = 0.003）。此外，腰交感神经切除术组患者的反应性充血指数与踝臂压力指数值显著相关（r = 0.848，P = 0.005）。鉴于血栓闭塞性脉管炎患者存在交感神经系统损害，我们应考虑这种受损系统对这些患者病情的后续影响。接受腰交感神经切除术治疗的患者可能更适合通过外周动脉张力测定试验来评估其内皮功能。
