Cui He-Rong, Bai Zhao-Fang, Song Hai-Bo, Jia Tian-Zhu, Wang Jia-Bo, Xiao Xiao-He
China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China.
Chengde Medical University, Chengde 067000, China.
Zhongguo Zhong Yao Za Zhi. 2016 Jan;41(2):333-339. doi: 10.4268/cjcmm20160227.
In recent years, the rapid growth of reports on fleece-flower root-caused liver damages has drawn wide attention of both at home and abroad, however, there were rare literature on toxicology of fleece-flower root in ancient Chinese medicine. But why there are so many reports on toxicology of fleece-flower root now compared with the ancient literature? As a typical tonic medicine, the clinical utility of fleece-flower root was largely limited by its standardization and reliability of processing methods in ancient Chinese medicine. The ancient processing methods of fleece-flower root emphasized nine times of steaming and nine times of drying, while the modern processes have been simplified into one time of steaming. Whether the differences between ancient and modern processing methods are the potential cause of the increased events of fleece-flower root-caused liver damages. We will make deep analysis and provide new clues and perspectives for the research on its toxicity. This article, therefore, would discuss the affecting factors and key problems in toxicity attenuation of fleece-flower root on the basis of sorting out the processing methods of fleece-flower root in ancient medical books and modern standards, in order to provide the reference for establishing specification for toxicity attenuation of fleece-flower root.
近年来，何首乌致肝损伤的报道迅速增多，引起了国内外的广泛关注，然而，中国古代医学中关于何首乌毒理学的文献却很少。但为何与古代文献相比，现在何首乌毒理学的报道如此之多呢？作为一种典型的滋补药，何首乌在古代中医临床应用中很大程度上受其炮制方法的规范和可靠性限制。古代何首乌炮制方法强调九蒸九晒，而现代工艺已简化为一次蒸制。古今炮制方法的差异是否是何首乌致肝损伤事件增多的潜在原因。我们将进行深入分析，为其毒性研究提供新的线索和视角。因此，本文将在梳理古代医书及现代标准中何首乌炮制方法的基础上，探讨何首乌毒性减毒的影响因素及关键问题，以期为制定何首乌毒性减毒规范提供参考。
