Yu He-Shui, Wang Lin-Lin, He Ying, Han Li-Feng, Ding Hui, Song Xin-Bo, Gao Xiu-Mei, Yun Nai-Ru, Li Zheng
College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Evid Based Complement Alternat Med. 2020 Sep 30;2020:6489648. doi: 10.1155/2020/6489648. eCollection 2020.
The roots of (PM) (He Shou Wu in Chinese) are one of the most commonly used tonic traditional Chinese medicines (TCMs) in China. PM is traditionally valued for its antiaging, liver- and kidney-tonifying, and hair-blackening effects. However, an increasing number of hepatotoxicity cases induced by PM attract the attention of scholars worldwide. Thus far, the potential liver injury compounds and the mechanism are still uncertain. The aim of this review is to provide comprehensive information on the potential hepatotoxic components and mechanism of PM based on the scientific literature. Moreover, perspectives for future investigations of hepatotoxic components are discussed. This study will build a new foundation for further study on the hepatotoxic components and mechanism of PM.
何首乌是中国最常用的滋补类传统中药之一。传统上，何首乌因其抗衰老、滋补肝肾和乌发功效而受到重视。然而，越来越多由何首乌引起的肝毒性病例引起了全球学者的关注。迄今为止，潜在的肝损伤化合物及其机制仍不明确。本综述的目的是基于科学文献，提供关于何首乌潜在肝毒性成分及其机制的全面信息。此外，还讨论了未来对肝毒性成分研究的展望。本研究将为进一步研究何首乌的肝毒性成分及其机制奠定新的基础。
