Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, People's Republic of China. Key Laboratory of Systems Bioengineering of the Ministry of Education, Tianjin University, Tianjin, 300072, People's Republic of China. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin, 300072, People's Republic of China.
Biomed Mater. 2017 Dec 28;13(1):015021. doi: 10.1088/1748-605X/aa89b2.
Electrospinning technology can easily produce different shaped fibrous structures, making them highly valuable to various biomedical applications. However, surface contamination of biomolecules, cells, or blood has emerged as a significant challenge to the success of electrospun devices, especially artificial blood vessels, catheters and wound dressings etc. Many efforts have been made to resist the surface non-specific biomolecules or cells adsorption, but most of them require complex pre-treatment processes, hard-to-remove metal catalysts or rigorous reaction conditions. In addition, the stability of antifouling coatings, especially in complex conditions, is still a major concern. In this work, inspired by the interpenetrating polymer network and reinforced concrete structure, an efficient and facile strategy for modifying hydrophobic electrospun meshes and tubes with antifouling zwitterionic hydrogels has been introduced. The resulting products could efficiently resist the adhesion of proteins, cells, or even fresh whole blood. Meanwhile, they could maintain the shapes and mechanical strength of the original electrospun structures. Furthermore, the hydrogel structures could retain stable in a physiological condition for at least 3 months. This paper provided a general antifouling and hydrophilicity surface modification strategy for various fibrous structures, and could be of great value for many biomedical applications where antifouling properties are critical.
静电纺丝技术可以轻松地制造出不同形状的纤维结构，这使得它们在各种生物医学应用中具有很高的价值。然而，生物分子、细胞或血液的表面污染已经成为静电纺丝器件成功应用的一个重大挑战，特别是人工血管、导管和伤口敷料等。人们已经做出了许多努力来抵抗表面非特异性生物分子或细胞的吸附，但大多数方法都需要复杂的预处理过程、难以去除的金属催化剂或严格的反应条件。此外，抗污涂层的稳定性，特别是在复杂条件下，仍然是一个主要关注点。在这项工作中，受互穿聚合物网络和钢筋混凝土结构的启发，我们提出了一种高效、简便的方法，即用抗污两性离子水凝胶对疏水静电纺丝网和管进行改性。所得产物可以有效地抵抗蛋白质、细胞甚至新鲜全血的黏附。同时，它们可以保持原始静电纺丝结构的形状和机械强度。此外，水凝胶结构在生理条件下至少可以稳定 3 个月。本文为各种纤维结构提供了一种通用的抗污和亲水表面改性策略，对于许多对抗污性能至关重要的生物医学应用具有重要价值。
