Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China.
Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China and Institute of Zhejiang University - Quzhou, 78 Jiuhua Boulevard North, Quzhou, Zhejiang 324000, China and Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biomedical Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210046, China.
J Mater Chem B. 2020 Mar 25;8(12):2443-2453. doi: 10.1039/c9tb02870f.
Although zwitterionic hydrogels exhibit excellent hemocompatibility, their extremely low tensile strength is an obstacle for their use in blood-contacting devices. Electrospun fiber scaffold-reinforced zwitterionic hydrogels are a possible solution to overcome the challenges of both mechanical strength and hemocompatibility. In this work, electrospun polyurethane (ePU) fiber scaffold-reinforced sulfobetaine methacrylate (SBMA) hydrogels (SRgels) were prepared. The SRgels exhibited 4.7 ± 0.5 MPa tensile fracture stress, while the interpenetration between the hydrogel and the fiber scaffold remained intact even under 2.8 MPa tensile stress at 3.0 mm mm-1 strain load; this confirms that the SRgels maintain excellent hemocompatibility for both blood cell adhesion and fibrinogen adsorption under physiological dynamic loading and that dynamically structural matching is achieved between the scaffold and the zwitterionic hydrogels. Mechano-induced self-enhancement was also observed after preloading more than 2.0 mm mm-1 tensile strain to resist fracture. In short, the preparation of SRgels can enable zwitterionic hydrogels to meet the requirement for mechanical strength in bio-applications as blood-contacting devices.
尽管两性离子水凝胶表现出优异的血液相容性，但它们极低的拉伸强度限制了其在与血液接触的装置中的应用。静电纺丝纤维支架增强两性离子水凝胶是克服机械强度和血液相容性挑战的一种可行方法。在这项工作中，制备了静电纺丝聚氨酯（ePU）纤维支架增强甲基丙烯酰磺基甜菜碱（SBMA）水凝胶（SRgels）。SRgels 表现出 4.7±0.5 MPa 的拉伸断裂应力，而在 3.0 mm mm-1 应变负载下 2.8 MPa 的拉伸应力下，水凝胶和纤维支架之间的互穿仍然保持完整；这证实了 SRgels 在生理动态负载下保持优异的血液相容性，既可以防止血细胞黏附，又可以防止纤维蛋白原吸附，并且在支架和两性离子水凝胶之间实现了动态结构匹配。在经受超过 2.0 mm mm-1 的拉伸应变预加载后，还观察到了机械诱导的自增强，以抵抗断裂。总之，SRgels 的制备可以使两性离子水凝胶满足作为与血液接触的装置的生物应用中对机械强度的要求。
