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印度北方邦西部头颈癌患者的流行病学概况及肿瘤部位相关危险因素分布分析

Epidemiological profile of head and neck cancer patients in Western Uttar Pradesh and analysis of distributions of risk factors in relation to site of tumor.

作者信息

Alam Mohammad Shadab, Siddiqui Shahid Ali, Perween Roshan

机构信息

Department of Radiotherapy, J.N. Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

Department of Obstetrics and Gynecology, J.N. Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

出版信息

J Cancer Res Ther. 2017 Jul-Sep;13(3):430-435. doi: 10.4103/0973-1482.180687.

Abstract

BACKGROUND

Head and neck cancers (HNCs) are a major form of cancers in India. The spectrum varies from place to place within the country because of significant diversified risk factors.

AIMS AND OBJECTIVE

To study, epidemiology and risk factors of HNC patients from Western Uttar Pradesh and to find out the correlation between risk factors and different anatomical regions involved.

MATERIALS AND METHODS

All patients with histologically confirmed diagnoses of HNC between January 2011 and December 2013 were selected from hospital records. Data regarding age, gender, addiction habits, site of tumor, and other details were obtained from their clinical records, and statistical analysis was done.

RESULTS AND CONCLUSION

HNC accounts for 21.2% of total body malignancy and 47% of all malignancies in males and 2.5% in females. Squamous cell carcinoma was the most common histological type (97%). Maximum incidence of HNC (>60%) was in 40-60 year of age. Male:female ratio was 16:1. Oral cancers were most common HNC in patients below 40 year age group, whereas carcinoma oropharynx and larynx were more common in patients above 40 year age group. Tobacco smoking was a most prevalent risk factor for carcinoma oropharynx, larynx, and hypopharynx. Tobacco chewing was a most prevalent risk factor in females, young males, and carcinoma buccal mucosa patients. Habit of tobacco consumption in HNC patients was much higher than their normal counterpart. Alcohols drinking alone was observed in <1% patient as a risk factor. In oral tongue cancer, smoking and tobacco chewing were equally prevalent. Habit of tobacco chewing and alcohol were significantly higher in carcinoma buccal mucosa than other HNC suggesting synergistic effect specific to this site.

摘要

背景

头颈癌(HNCs)是印度癌症的主要形式。由于显著多样的风险因素,该国不同地区的疾病谱有所不同。

目的

研究印度北方邦西部HNC患者的流行病学和风险因素,并找出风险因素与受累不同解剖区域之间的相关性。

材料与方法

从医院记录中选取2011年1月至2013年12月间所有经组织学确诊为HNC的患者。从他们的临床记录中获取有关年龄、性别、成瘾习惯、肿瘤部位及其他细节的数据,并进行统计分析。

结果与结论

HNC占全身恶性肿瘤的21.2%,男性所有恶性肿瘤的47%,女性的2.5%。鳞状细胞癌是最常见的组织学类型(97%)。HNC的最高发病率(>60%)出现在40 - 60岁年龄段。男女比例为16:1。口腔癌是40岁以下年龄组患者中最常见的HNC,而口咽癌和喉癌在40岁以上年龄组患者中更为常见。吸烟是口咽癌、喉癌和下咽癌最普遍的风险因素。咀嚼烟草是女性、年轻男性和颊黏膜癌患者中最普遍的风险因素。HNC患者的烟草消费习惯远高于正常人群。单独饮酒作为风险因素在不到1%的患者中观察到。在口腔舌癌中,吸烟和咀嚼烟草同样普遍。颊黏膜癌患者的咀嚼烟草和饮酒习惯显著高于其他HNC,表明该部位存在协同作用。

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