Aguayo Francisco, Perez-Dominguez Francisco, Osorio Julio C, Oliva Carolina, Calaf Gloria M
Departamento de Biomedicina, Facultad de Medicina, Universidad de Tarapacá, Arica 1000000, Chile.
Laboratorio de Oncovirología, Programa de Virología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 8380000, Chile.
Biology (Basel). 2023 Apr 29;12(5):672. doi: 10.3390/biology12050672.
High-risk human papillomaviruses (HR-HPVs) are the causal agents of cervical, anogenital and a subset of head and neck carcinomas (HNCs). Indeed, oropharyngeal cancers are a type of HNC highly associated with HR-HPV infections and constitute a specific clinical entity. The oncogenic mechanism of HR-HPV involves E6/E7 oncoprotein overexpression for promoting cell immortalization and transformation, through the downregulation of p53 and pRB tumor suppressor proteins, among other cellular targets. Additionally, E6/E7 proteins are involved in promoting PI3K/AKT/mTOR signaling pathway alterations. In this review, we address the relationship between HR-HPV and PI3K/AKT/mTOR signaling pathway activation in HNC with an emphasis on its therapeutic importance.
高危型人乳头瘤病毒（HR-HPV）是宫颈癌、肛门生殖器癌以及一部分头颈癌（HNC）的致病因子。事实上，口咽癌是一种与HR-HPV感染高度相关的HNC类型，构成了一种特定的临床实体。HR-HPV的致癌机制涉及E6/E7癌蛋白的过表达，通过下调p53和pRB肿瘤抑制蛋白等细胞靶点来促进细胞永生化和转化。此外，E6/E7蛋白还参与促进PI3K/AKT/mTOR信号通路的改变。在本综述中，我们阐述了HNC中HR-HPV与PI3K/AKT/mTOR信号通路激活之间的关系，并重点强调了其治疗意义。
