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黄夹竹桃中毒致急性心肌梗死

Acute myocardial infarction in yellow oleander poisoning.

作者信息

Anandhi D, Prakash Raju K N J, Basha M H, Pandit V R

机构信息

Department of Emergency Medicine and Trauma, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

出版信息

J Postgrad Med. 2018 Apr-Jun;64(2):123-126. doi: 10.4103/jpgm.JPGM_141_17.

DOI:10.4103/jpgm.JPGM_141_17
PMID:28862240
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5954810/
Abstract

Self-harm by consuming yellow oleander seeds has become more frequent in South Asian countries, especially Sri Lanka and in southern parts of India. Yellow oleander poisoning usually presents with gastrointestinal, cardiovascular, and neurological manifestations as well as electrolyte abnormalities. Cardiac effects can manifest as nearly any type of dysrhythmia and sudden death with very few premonitory signs. To our knowledge yellow oleander poisoning related acute myocardial infarction has not yet been reported. We report a 37-year-old man with yellow oleander poisoning who had normal sinus rhythm at presentation but within few hours developed acute ST-segment myocardial infarction.

摘要

在南亚国家,尤其是斯里兰卡和印度南部,食用黄花夹竹桃种子进行自我伤害的情况变得越来越频繁。黄花夹竹桃中毒通常表现为胃肠道、心血管和神经方面的症状以及电解质异常。心脏影响几乎可以表现为任何类型的心律失常和猝死,且几乎没有先兆症状。据我们所知,尚未有关于黄花夹竹桃中毒相关急性心肌梗死的报道。我们报告了一名37岁的黄花夹竹桃中毒男性患者,其就诊时窦性心律正常,但在数小时内发展为急性ST段心肌梗死。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/5954810/5233ff61d3cd/JPGM-64-123-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/5954810/174f97fc3b09/JPGM-64-123-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/5954810/89b670af70b7/JPGM-64-123-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/5954810/5233ff61d3cd/JPGM-64-123-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/5954810/174f97fc3b09/JPGM-64-123-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/5954810/89b670af70b7/JPGM-64-123-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b26/5954810/5233ff61d3cd/JPGM-64-123-g003.jpg

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A study of socio clinical, biochemical and electrocardiographic changes of yellow oleander seed poisoning in India.印度黄夹竹桃种子中毒的社会临床、生化及心电图变化研究
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本文引用的文献

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Br J Clin Pharmacol. 2016 Mar;81(3):488-95. doi: 10.1111/bcp.12814. Epub 2015 Dec 15.
2
Increased acetylcholine esterase activity produced by the administration of an aqueous extract of the seed kernel of Thevetia peruviana and its role on acute and subchronic intoxication in mice.秘鲁天芥菜种子内核水提取物给药所产生的乙酰胆碱酯酶活性增加及其对小鼠急性和亚慢性中毒的作用。
Pharmacogn Mag. 2014 Jan;10(Suppl 1):S171-5. doi: 10.4103/0973-1296.127370.
3
Yellow oleander poisoning in eastern province: an analysis of admission and outcome.
Turk J Emerg Med. 2019 Jan 3;19(3):115-116. doi: 10.1016/j.tjem.2018.12.002. eCollection 2019 Jul.
东部省份的黄夹竹桃中毒:入院情况及预后分析
Indian J Med Sci. 2013 Jul-Aug;67(7-8):178-83.
4
Applied clinical pharmacology and public health in rural Asia--preventing deaths from organophosphorus pesticide and yellow oleander poisoning.亚洲农村的应用临床药理学和公共卫生——预防有机磷农药和夹竹桃中毒导致的死亡。
Br J Clin Pharmacol. 2013 May;75(5):1175-88. doi: 10.1111/j.1365-2125.2012.04449.x.
5
Fructose-1, 6-diphosphate (FDP) as a novel antidote for yellow oleander-induced cardiac toxicity: a randomized controlled double blind study.果糖-1,6-二磷酸(FDP)作为夹竹桃引起的心脏毒性的新型解毒剂:一项随机对照双盲研究。
BMC Emerg Med. 2010 Jun 29;10:15. doi: 10.1186/1471-227X-10-15.
6
A review of the natural history, toxinology, diagnosis and clinical management of Nerium oleander (common oleander) and Thevetia peruviana (yellow oleander) poisoning.夹竹桃和黄花夹竹桃中毒的自然史、毒素学、诊断和临床处理综述。
Toxicon. 2010 Sep 1;56(3):273-81. doi: 10.1016/j.toxicon.2010.03.026. Epub 2010 May 8.
7
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Clin Toxicol (Phila). 2009 Mar;47(3):206-12. doi: 10.1080/15563650902824001.
8
Immediate control of life-threatening digoxin intoxication in a child by use of digoxin-specific antibody fragments (Fab).使用地高辛特异性抗体片段(Fab)立即控制儿童危及生命的地高辛中毒。
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9
Acute plant poisoning and antitoxin antibodies.急性植物中毒与抗毒素抗体
J Toxicol Clin Toxicol. 2003;41(3):309-15. doi: 10.1081/clt-120021116.