Subramani Murugan, Anbarasan Mudali, Deepalatha Shanmugam, Muthumani Lakshmi Narayanan, Mahesh Mallu Azmeera
Department of General Medicine, K.A.P Viswanatham Govt Medical College, Trichy - 17, India.
Bioinformation. 2023 Mar 31;19(3):244-250. doi: 10.6026/97320630019. eCollection 2023.
Yellow oleander (), which belongs to the Apocyanaceae family, is a common shrub seen throughout the tropics. All parts of the plant contain high concentrations of cardiac glycosides, which are toxic to cardiac muscle and the autonomic nervous system. The main objective of this study was to socio-clinical, biochemical and electrocardiographic changes of yellow oleander seed poisoning. This prospective observational study was conducted over a period of 6 months (March 2022 to September 2022). Oleander seed poison in most prevalent in the 21-40 years age. More the crushed seeds consumed and the delay to admission to the hospital for treatment poorer was the outcome. The most common GI symptoms of yellow oleander poisoning were vomiting (58 %), abdominal pain (28%), diarrhoea (9%), and palpitations (20%), dizziness (18%).Serum potassium levels that were measured during the admission were directly related to the ECG changes. ECG changes were more observed with patients those who consumed seeds in crushed form and this difference is statistically significant (P = 0.0001). Higher incidence of cardiotoxicity was noted with patients those who consumed poison on empty stomach compare to who consumed after food. The Electrocardiographic manifestations was found even with consumption of one seed, number of seeds consumptions independent of cardiotoxicity.Additonally higher mean Potassium value observed in patients who had cardiotoxicity when compared to patient who had no cardiotoxicity. Death of the patients in yellow oleander seed poisoning was independent of quantity of the seeds they have ingested.
黄花夹竹桃属于夹竹桃科，是热带地区常见的灌木。该植物的所有部位都含有高浓度的强心苷，对心肌和自主神经系统有毒性。本研究的主要目的是探讨黄花夹竹桃种子中毒的社会临床、生化和心电图变化。这项前瞻性观察研究为期6个月（2022年3月至2022年9月）。黄花夹竹桃种子中毒在21至40岁年龄段最为普遍。食用的碾碎种子越多，延迟入院治疗，预后越差。黄花夹竹桃中毒最常见的胃肠道症状是呕吐（58%）、腹痛（28%）、腹泻（9%）、心悸（20%）、头晕（18%）。入院时测量的血清钾水平与心电图变化直接相关。食用碾碎种子的患者心电图变化更为明显，且这种差异具有统计学意义（P = 0.0001）。与饭后食用中毒者相比，空腹食用中毒者的心脏毒性发生率更高。即使只食用一粒种子也会出现心电图表现，食用种子的数量与心脏毒性无关。此外，与无心脏毒性的患者相比，有心脏毒性的患者平均钾值更高。黄花夹竹桃种子中毒患者的死亡与摄入的种子数量无关。
