交感神经系统参与冷适应大鼠棕色脂肪组织的脂肪分解活性。
Involvement of the sympathetic nervous system in lipolytic activity in brown adipose tissue of cold acclimated rats.
作者信息
Laury M C, Chapey M F, Portet R
出版信息
Comp Biochem Physiol A Comp Physiol. 1987;87(1):197-203. doi: 10.1016/0300-9629(87)90446-4.
In cold acclimated rats, in vitro, NE led to a significant increase in release of FFA and glycerol in denervated IBAT. In vivo, study of arteriovenous differences showed that the denervated BAT loses its full capacity to utilize FFA and glycerol released by NE. After denervation an increase of blood flow in Sulzer's vein was observed. This effect appeared immediately after intervention whereas the effect on fat metabolism appeared later. In cold acclimated rats, the sympathetic nervous system appears to be an important regulator of fatty acid metabolism in BAT.
在冷适应大鼠中，体外实验表明，去神经支配的褐色脂肪组织（IBAT）中，去甲肾上腺素（NE）导致游离脂肪酸（FFA）和甘油释放显著增加。在体内实验中，动静脉差异研究表明，去神经支配的褐色脂肪组织（BAT）利用去甲肾上腺素（NE）释放的游离脂肪酸（FFA）和甘油的能力完全丧失。去神经支配后，观察到苏尔泽静脉血流量增加。这种效应在干预后立即出现，而对脂肪代谢的影响则在之后出现。在冷适应大鼠中，交感神经系统似乎是褐色脂肪组织（BAT）中脂肪酸代谢的重要调节因子。
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