Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Université catholique de Louvain, Brussels, Belgium.
Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Université catholique de Louvain, Brussels, Belgium; Walloon Excellence in Life sciences and BIOtechnology (WELBIO), Louvain Drug Research Institute, UCL, B-1200 Brussels, Belgium.
J Nutr Biochem. 2017 Nov;49:15-21. doi: 10.1016/j.jnutbio.2017.07.008. Epub 2017 Jul 24.
Fat browning has emerged as an attractive target for the treatment of obesity and related metabolic disorders. Its activation leads to increased energy expenditure and reduced adiposity, thus contributing to a better energy homeostasis. Green tea extracts (GTEs) were shown to attenuate obesity and low-grade inflammation and to induce the lipolytic pathway in the white adipose tissue (WAT) of mice fed a high-fat diet. The aim of the present study was to determine whether the antiobesity effect of an extract from green tea leaves was associated with the activation of browning in the WAT and/or the inhibition of whitening in the brown adipose tissue (BAT) in HF-diet induced obese mice. Mice were fed a control diet or an HF diet supplemented with or without 0.5% polyphenolic GTE for 8 weeks. GTE supplementation significantly reduced HF-induced adiposity (WAT and BAT) and HF-induced inflammation in WAT. Histological analysis revealed that GTE reduced the adipocyte size in the WAT and the lipid droplet size in the BAT. Markers of browning were induced in the WAT upon GTE treatment, whereas markers of HF-induced whitening were reduced in the BAT. These results suggest that browning activation in the WAT and whitening reduction in the BAT by the GTE could participate to the improvement of metabolic and inflammatory disorders mediated by GTE upon HF diet. Our study emphasizes the importance of using GTE as a nutritional tool to activate browning and to decrease fat storage in all adipose tissues, which attenuate obesity.
脂肪棕色化已成为治疗肥胖症和相关代谢紊乱的一个有吸引力的靶点。它的激活导致能量消耗增加和脂肪减少，从而有助于更好的能量平衡。绿茶提取物（GTE）被证明可以减轻肥胖和低度炎症，并在高脂肪饮食喂养的小鼠的白色脂肪组织（WAT）中诱导脂肪分解途径。本研究的目的是确定来自绿茶提取物的抗肥胖作用是否与 WAT 中的棕色化激活和/或在 HF 饮食诱导肥胖小鼠的棕色脂肪组织（BAT）中的白色化抑制有关。小鼠喂食对照饮食或补充 0.5%多酚 GTE 的 HF 饮食 8 周。GTE 补充显著降低了 HF 诱导的肥胖（WAT 和 BAT）和 WAT 中的 HF 诱导的炎症。组织学分析显示，GTE 减少了 WAT 中的脂肪细胞大小和 BAT 中的脂质滴大小。GTE 处理诱导了 WAT 中的棕色化标志物，而 HF 诱导的 BAT 中的白色化标志物减少。这些结果表明，GTE 在 WAT 中诱导的棕色化激活和在 BAT 中诱导的白色化减少可能有助于改善 HF 饮食介导的代谢和炎症紊乱。我们的研究强调了使用 GTE 作为一种营养工具来激活棕色化和减少所有脂肪组织中的脂肪储存，从而减轻肥胖的重要性。
