McElroy Anita K, Akondy Rama S, Harmon Jessica R, Ellebedy Ali H, Cannon Deborah, Klena John D, Sidney John, Sette Alessandro, Mehta Aneesh K, Kraft Colleen S, Lyon Marshall G, Varkey Jay B, Ribner Bruce S, Nichol Stuart T, Spiropoulou Christina F
Departments of Pediatrics.
CDC Viral Special Pathogens Branch, Atlanta, Georgia.
J Infect Dis. 2017 Jun 15;215(12):1862-1872. doi: 10.1093/infdis/jix201.
A nurse who acquired Lassa virus infection in Togo in the spring of 2016 was repatriated to the United States for care at Emory University Hospital. Serial sampling from this patient permitted the characterization of several aspects of the innate and cellular immune responses to Lassa virus. Although most of the immune responses correlated with the kinetics of viremia resolution, the CD8 T-cell response was of surprisingly high magnitude and prolonged duration, implying prolonged presentation of viral antigens. Indeed, long after viremia resolution, there was persistent viral RNA detected in the semen of the patient, accompanied by epididymitis, suggesting the male reproductive tract as 1 site of antigen persistence. Consistent with the magnitude of acute T-cell responses, the patient ultimately developed long-term, polyfunctional memory T-cell responses to Lassa virus.
一名于2016年春季在多哥感染拉沙病毒的护士被遣返回美国，在埃默里大学医院接受治疗。对该患者进行的系列采样使得能够对拉沙病毒天然免疫反应和细胞免疫反应的多个方面进行特征描述。虽然大多数免疫反应与病毒血症消退的动力学相关，但CD8 T细胞反应的强度惊人地高且持续时间长，这意味着病毒抗原的呈递持续时间较长。事实上，在病毒血症消退很久之后，在该患者的精液中检测到持续的病毒RNA，并伴有附睾炎，这表明男性生殖道是抗原持续存在的一个部位。与急性T细胞反应的强度一致，该患者最终对拉沙病毒产生了长期的、多功能的记忆T细胞反应。
