Esteva Lourdes, Vargas Cristobal, Vargas de León Cruz
Facultad de Ciencias, UNAM, México, D.F. 04510, Mexico.
Departamento de Control Automático, CINVESTAV-IPN, México, D.F. 07000, Mexico.
Math Biosci. 2017 Nov;293:46-55. doi: 10.1016/j.mbs.2017.08.006. Epub 2017 Aug 31.
Leishmaniasis is a parasite disease transmitted by the bites of sandflies. Cutaneous leishmaniasis is the most common form of the disease and it is endemic in the Americas. Around 70 animal species, including humans, have been found as natural reservoir hosts of leishmania parasites. Among the reservoirs, dogs are the most important ones due to their proximity to the human habitat. Infection by leishmaniasis does not invariably cause illness in the host, and it also can remain asymptomatic for a long period, specially in dogs. In this work we formulate a model to study the transmission of the disease among the vector, humans and dogs. Our main objective is to asses the impact of dogs as a reservoir as well as the impact of asymptomatic humans and dogs on the spread of leishmaniasis. For this end we calculate the Basic Reproduction Number of the disease and we carry out sensitivity analysis of this parameter with respect to the epidemiological and demographic parameters.
利什曼病是一种由白蛉叮咬传播的寄生虫病。皮肤利什曼病是该疾病最常见的形式,在美洲呈地方性流行。已发现约70种动物物种,包括人类,是利什曼原虫寄生虫的天然宿主。在这些宿主中,狗因其与人类栖息地接近而最为重要。感染利什曼病并不一定会在宿主身上引发疾病,而且它也可能长期无症状,尤其是在狗身上。在这项工作中,我们构建了一个模型来研究该疾病在病媒、人类和狗之间的传播。我们的主要目标是评估狗作为宿主的影响以及无症状人类和狗对利什曼病传播的影响。为此,我们计算了该疾病的基本再生数,并对该参数相对于流行病学和人口统计学参数进行了敏感性分析。